DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1997 |
|
| 5 | 1521 |
|
| 6 | 1107 |
|
| 7 | 564 |
|
| 8 | 303 |
|
| 9 | 239 |
|
| 10 | 188 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10384 |
|
4797 |
|
| 2 | 1080 |
|
184 |
|
| 3 | 318 |
|
308 |
|
| 4 | 5 |
|
64 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7584 |
|
4327 |
|
| 2 | 880 |
|
611 |
|
| 3 | 221 |
|
||
| 4 | 136 |
|
||
| 5 | 11 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5370.836193 |
|
| 2 | -998.82079 |
|
| 3 | -665.023195 |
|
| 4 | -553.836537 |
|
| 5 | -435.276003 |
|
| 6 | -399.505448 |
|
| 7 | -331.299647 |
|
| 8 | -323.012436 |
|
| 9 | -236.208617 |
|
| 10 | -212.974078 |
|
| 11 | -179.999908 |
|
| 12 | -88.517975 |
|
| 13 | -67.702701 |
|
| 14 | -33.798488 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9607.366079 |
|
-9831.734175 |
|
| 2 | -1601.533512 |
|
-937.297823 |
|
| 3 | -809.594007 |
|
-350.140672 |
|
| 4 | -806.695391 |
|
-334.782228 |
|
| 5 | -606.373625 |
|
-236.848899 |
|
| 6 | -594.848267 |
|
-177.324114 |
|
| 7 | -373.660455 |
|
-44.773954 |
|
| 8 | -194.857196 |
|
-22.445767 |
|
| 9 | -189.593191 |
|
-21.880139 |
|
| 10 | -174.390253 |
|
||
| 11 | -128.350794 |
|
||
| 12 | -112.562252 |
|
||
| 13 | -89.926863 |
|
||
| 14 | -41.677747 |
|
||
| 15 | -33.715246 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -11994.12225 |
|
-10933.750917 |
|
| 2 | -973.00717 |
|
-578.298608 |
|
| 3 | -576.341543 |
|
-283.182193 |
|
| 4 | -566.035209 |
|
-258.580604 |
|
| 5 | -334.783647 |
|
-202.085812 |
|
| 6 | -125.580678 |
|
-147.252697 |
|
| 7 | -116.59639 |
|
-127.420318 |
|
| 8 | -99.689691 |
|
-53.013811 |
|
| 9 | -73.511886 |
|
-45.435107 |
|
| 10 | -68.421453 |
|
-29.852916 |
|
| 11 | -61.891531 |
|
-28.708301 |
|
| 12 | -48.210139 |
|
||
| 13 | -41.022747 |
|
||
| 14 | -16.719308 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 2.5e-118 |
|
| 3 | 2.4e-65 |
|
| 4 | 7.4e-55 |
|
| 5 | 5.7e-34 |
|
| 6 | 1.3e-08 |
|
| 7 | 0.91 |
|
| 8 | 1.3e-16 |
|
| 9 | 0.0001 |
|
| 10 | 5.2 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3e-70 |
|
1.1e-33 |
|
| 3 | 1.9e-14 |
|
3.8e-16 |
|
| 4 | 0.015 |
|
14000.0 |
|
| 5 | 1.4 |
|
63000.0 |
|
| 6 | 2700.0 |
|
190000.0 |
|
| 7 | 2900.0 |
|
390000.0 |
|
| 8 | 6700.0 |
|
830000.0 |
|
| 9 | 5000.0 |
|
950000.0 |
|
| 10 | 330000.0 |
|
640000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.8e-27 |
|
3700.0 |
|
| 3 | 2.4e-10 |
|
130000.0 |
|
| 4 | 920.0 |
|
530000.0 |
|
| 5 | 2300.0 |
|
530000.0 |
|
| 6 | 4900.0 |
|
920000.0 |
|
| 7 | 5100.0 |
|
1300000.0 |
|
| 8 | 31000.0 |
|
2000000.0 |
|
| 9 | 750000.0 |
|
2200000.0 |
|
| 10 | 940000.0 |
|
2200000.0 |
|