DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1558 |
|
| 6 | 1105 |
|
| 7 | 493 |
|
| 8 | 212 |
|
| 9 | 119 |
|
| 10 | 19 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11697 |
|
10096 |
|
| 2 | 4928 |
|
344 |
|
| 3 | 628 |
|
||
| 4 | 2 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14797 |
|
15802 |
|
| 2 | 1364 |
|
1271 |
|
| 3 | 423 |
|
153 |
|
| 4 | 69 |
|
||
| 5 | 28 |
|
||
| 6 | 15 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7025.960047 |
|
| 2 | -3109.403489 |
|
| 3 | -2877.848195 |
|
| 4 | -2738.831672 |
|
| 5 | -1988.416946 |
|
| 6 | -1770.080232 |
|
| 7 | -1591.38706 |
|
| 8 | -1353.430446 |
|
| 9 | -1345.511865 |
|
| 10 | -1334.542853 |
|
| 11 | -965.569012 |
|
| 12 | -871.517103 |
|
| 13 | -868.532955 |
|
| 14 | -854.468978 |
|
| 15 | -815.934739 |
|
| 16 | -801.757654 |
|
| 17 | -566.634192 |
|
| 18 | -344.018989 |
|
| 19 | -234.21327 |
|
| 20 | -208.236916 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8393.654678 |
|
-14558.697961 |
|
| 2 | -3386.134064 |
|
-3131.073495 |
|
| 3 | -1134.70508 |
|
-599.019754 |
|
| 4 | -1001.497101 |
|
-510.47697 |
|
| 5 | -831.068024 |
|
-357.412819 |
|
| 6 | -709.408132 |
|
-306.71548 |
|
| 7 | -661.974125 |
|
-132.719807 |
|
| 8 | -368.984008 |
|
-61.855898 |
|
| 9 | -339.499751 |
|
-60.727885 |
|
| 10 | -163.926783 |
|
-57.562632 |
|
| 11 | -154.304563 |
|
-45.075549 |
|
| 12 | -143.592172 |
|
-45.039976 |
|
| 13 | -111.452166 |
|
-36.557142 |
|
| 14 | -104.724721 |
|
||
| 15 | -95.209835 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -11714.999656 |
|
-16071.112993 |
|
| 2 | -2951.541607 |
|
-3644.097702 |
|
| 3 | -1904.906974 |
|
-3504.521267 |
|
| 4 | -1545.261506 |
|
-2764.645413 |
|
| 5 | -1506.644505 |
|
-1072.003693 |
|
| 6 | -941.820815 |
|
-772.459373 |
|
| 7 | -890.817509 |
|
-405.611921 |
|
| 8 | -448.20169 |
|
-256.690076 |
|
| 9 | -355.940165 |
|
-163.064612 |
|
| 10 | -104.533568 |
|
-140.904283 |
|
| 11 | -88.681534 |
|
-110.054801 |
|
| 12 | -29.866989 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.3e-183 |
|
| 2 | 9.2e-80 |
|
| 3 | 1.6e-75 |
|
| 4 | 5.6e-25 |
|
| 5 | 6.5e-25 |
|
| 6 | 2.9e-22 |
|
| 7 | 2.3e-10 |
|
| 8 | 3.1e-06 |
|
| 9 | 2.2e-06 |
|
| 10 | 0.00028 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.3e-89 |
|
2.9e-105 |
|
| 3 | 2.6e-80 |
|
1.6e-16 |
|
| 4 | 3e-78 |
|
0.2 |
|
| 5 | 8.4e-75 |
|
200000.0 |
|
| 6 | 1.5e-21 |
|
210000.0 |
|
| 7 | 4.4e-07 |
|
280000.0 |
|
| 8 | 8.7e-05 |
|
360000.0 |
|
| 9 | 6.3e-06 |
|
360000.0 |
|
| 10 | 0.35 |
|
380000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.8e-118 |
|
2.3e-58 |
|
| 3 | 2e-29 |
|
1e-61 |
|
| 4 | 7.5e-28 |
|
2.1e-37 |
|
| 5 | 3.7e-05 |
|
8100.0 |
|
| 6 | 4.4e-05 |
|
100000.0 |
|
| 7 | 1.9e-07 |
|
380000.0 |
|
| 8 | 280.0 |
|
820000.0 |
|
| 9 | 4300.0 |
|
2300000.0 |
|
| 10 | 17000.0 |
|
2400000.0 |
|