DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1807 |
|
| 6 | 1046 |
|
| 7 | 510 |
|
| 8 | 365 |
|
| 9 | 221 |
|
| 10 | 130 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 20000 |
|
6524 |
|
| 2 | 313 |
|
||
| 3 | 655 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15699 |
|
11560 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7939.571858 |
|
| 2 | -1788.822853 |
|
| 3 | -1660.693387 |
|
| 4 | -914.598152 |
|
| 5 | -863.044493 |
|
| 6 | -572.214855 |
|
| 7 | -521.641909 |
|
| 8 | -461.11506 |
|
| 9 | -454.79595 |
|
| 10 | -373.373894 |
|
| 11 | -372.842297 |
|
| 12 | -331.064574 |
|
| 13 | -229.517552 |
|
| 14 | -224.51258 |
|
| 15 | -215.063493 |
|
| 16 | -194.156278 |
|
| 17 | -118.960414 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -13069.989165 |
|
-12441.220882 |
|
| 2 | -1555.321075 |
|
-1389.882715 |
|
| 3 | -715.282067 |
|
-377.353021 |
|
| 4 | -544.316381 |
|
-222.448885 |
|
| 5 | -535.481498 |
|
-113.017577 |
|
| 6 | -494.719767 |
|
-102.525241 |
|
| 7 | -473.33683 |
|
-61.773667 |
|
| 8 | -404.805538 |
|
-29.293631 |
|
| 9 | -205.398428 |
|
-11.974012 |
|
| 10 | -180.267212 |
|
||
| 11 | -167.084418 |
|
||
| 12 | -144.868579 |
|
||
| 13 | -104.003281 |
|
||
| 14 | -73.494493 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15705.879251 |
|
-14866.278748 |
|
| 2 | -1253.820187 |
|
-1524.737825 |
|
| 3 | -822.74562 |
|
-419.956277 |
|
| 4 | -369.295503 |
|
-234.13868 |
|
| 5 | -236.509789 |
|
-188.330331 |
|
| 6 | -224.463685 |
|
-92.912832 |
|
| 7 | -138.779474 |
|
-50.636738 |
|
| 8 | -81.081168 |
|
-30.891148 |
|
| 9 | -64.648259 |
|
||
| 10 | -57.655887 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.7e-236 |
|
| 3 | 5.8e-58 |
|
| 4 | 5.4e-32 |
|
| 5 | 1.5e-20 |
|
| 6 | 1.8e-17 |
|
| 7 | 2.6e-14 |
|
| 8 | 8.2e-07 |
|
| 9 | 7e-08 |
|
| 10 | 0.03 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.1e-58 |
|
4.2e-61 |
|
| 3 | 4.8e-41 |
|
0.18 |
|
| 4 | 3.4e-09 |
|
130000.0 |
|
| 5 | 3.4e-09 |
|
7100.0 |
|
| 6 | 3.4e-09 |
|
900000.0 |
|
| 7 | 3.4e-09 |
|
900000.0 |
|
| 8 | 3.4e-09 |
|
900000.0 |
|
| 9 | 3.4e-09 |
|
1200000.0 |
|
| 10 | 3.4e-09 |
|
1500000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.5e-177 |
|
1.1e-19 |
|
| 3 | 1.2e-05 |
|
0.0021 |
|
| 4 | 28000.0 |
|
3700.0 |
|
| 5 | 31000.0 |
|
6600.0 |
|
| 6 | 190000.0 |
|
790000.0 |
|
| 7 | 210000.0 |
|
880000.0 |
|
| 8 | 250000.0 |
|
1500000.0 |
|
| 9 | 670000.0 |
|
1700000.0 |
|
| 10 | 1100000.0 |
|
2000000.0 |
|