DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1993 |
|
| 5 | 1398 |
|
| 6 | 691 |
|
| 7 | 199 |
|
| 8 | 36 |
|
| 9 | 17 |
|
| 10 | 9 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11999 |
|
12184 |
|
| 2 | 907 |
|
367 |
|
| 3 | 1847 |
|
1037 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11483 |
|
11100 |
|
| 2 | 1864 |
|
1873 |
|
| 3 | 202 |
|
||
| 4 | 59 |
|
||
| 5 | 15 |
|
||
| 6 | 4 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5948.253465 |
|
| 2 | -4641.634084 |
|
| 3 | -2037.456047 |
|
| 4 | -1990.123471 |
|
| 5 | -1621.477994 |
|
| 6 | -1130.559476 |
|
| 7 | -867.722193 |
|
| 8 | -799.206508 |
|
| 9 | -789.78852 |
|
| 10 | -721.199406 |
|
| 11 | -646.206798 |
|
| 12 | -614.259887 |
|
| 13 | -522.286811 |
|
| 14 | -449.362971 |
|
| 15 | -349.048879 |
|
| 16 | -243.11734 |
|
| 17 | -202.583585 |
|
| 18 | -185.010414 |
|
| 19 | -141.023013 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6736.814265 |
|
-13320.873569 |
|
| 2 | -3079.128383 |
|
-3877.837343 |
|
| 3 | -960.611248 |
|
-904.784286 |
|
| 4 | -866.242637 |
|
-638.365927 |
|
| 5 | -696.538982 |
|
-337.268249 |
|
| 6 | -660.702685 |
|
-336.830939 |
|
| 7 | -623.010219 |
|
-330.969808 |
|
| 8 | -603.161279 |
|
-71.033188 |
|
| 9 | -524.79096 |
|
-49.401978 |
|
| 10 | -483.524674 |
|
-45.274078 |
|
| 11 | -362.970099 |
|
-39.668379 |
|
| 12 | -316.978397 |
|
-29.286586 |
|
| 13 | -311.2087 |
|
||
| 14 | -294.332833 |
|
||
| 15 | -283.103882 |
|
||
| 16 | -249.817387 |
|
||
| 17 | -238.863154 |
|
||
| 18 | -227.161886 |
|
||
| 19 | -225.258232 |
|
||
| 20 | -202.350006 |
|
||
| 21 | -201.133371 |
|
||
| 22 | -147.313491 |
|
||
| 23 | -115.683435 |
|
||
| 24 | -41.958787 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8235.705849 |
|
-10314.223998 |
|
| 2 | -864.359966 |
|
-544.747608 |
|
| 3 | -448.795244 |
|
-392.467246 |
|
| 4 | -390.084181 |
|
-312.473296 |
|
| 5 | -305.369571 |
|
-190.62723 |
|
| 6 | -223.130437 |
|
-166.394196 |
|
| 7 | -204.185779 |
|
-152.820352 |
|
| 8 | -93.779785 |
|
-151.835119 |
|
| 9 | -93.572945 |
|
-73.498474 |
|
| 10 | -84.537168 |
|
-72.436312 |
|
| 11 | -73.981651 |
|
-56.072287 |
|
| 12 | -63.80065 |
|
-48.494723 |
|
| 13 | -45.718262 |
|
-46.133838 |
|
| 14 | -7.098996 |
|
-25.820829 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.2e-224 |
|
| 2 | 6.9e-74 |
|
| 3 | 4.8e-69 |
|
| 4 | 1.9e-54 |
|
| 5 | 1.4e-65 |
|
| 6 | 1.1e-38 |
|
| 7 | 3.8e-05 |
|
| 8 | 8.5e-06 |
|
| 9 | 0.00024 |
|
| 10 | 0.0067 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-137 |
|
9.3e-88 |
|
| 3 | 1.7e-79 |
|
1500.0 |
|
| 4 | 2.2e-14 |
|
12000.0 |
|
| 5 | 8.3e-13 |
|
3000.0 |
|
| 6 | 2.6e-07 |
|
150000.0 |
|
| 7 | 7.8e-07 |
|
190000.0 |
|
| 8 | 1.4e-05 |
|
910000.0 |
|
| 9 | 54.0 |
|
940000.0 |
|
| 10 | 170.0 |
|
1000000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.8e-35 |
|
260.0 |
|
| 3 | 3.4e-11 |
|
15000.0 |
|
| 4 | 1300.0 |
|
29000.0 |
|
| 5 | 4800.0 |
|
140000.0 |
|
| 6 | 6900.0 |
|
160000.0 |
|
| 7 | 14000.0 |
|
210000.0 |
|
| 8 | 7600.0 |
|
580000.0 |
|
| 9 | 36000.0 |
|
580000.0 |
|
| 10 | 54000.0 |
|
580000.0 |
|