DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1999 |
|
| 2 | 2000 |
|
| 3 | 1999 |
|
| 4 | 1993 |
|
| 5 | 1549 |
|
| 6 | 1106 |
|
| 7 | 605 |
|
| 8 | 192 |
|
| 9 | 93 |
|
| 10 | 63 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 20000 |
|
10794 |
|
| 2 | 1179 |
|
||
| 3 | 90 |
|
||
| 4 | 26 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12087 |
|
11109 |
|
| 2 | 3531 |
|
1377 |
|
| 3 | 33 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -7727.043221 |
|
| 2 | -2104.661167 |
|
| 3 | -2013.780172 |
|
| 4 | -1722.516322 |
|
| 5 | -1448.11502 |
|
| 6 | -1280.004494 |
|
| 7 | -1278.642516 |
|
| 8 | -1274.599822 |
|
| 9 | -1249.905946 |
|
| 10 | -751.743675 |
|
| 11 | -745.718537 |
|
| 12 | -730.285189 |
|
| 13 | -702.412125 |
|
| 14 | -651.98668 |
|
| 15 | -615.353086 |
|
| 16 | -424.12785 |
|
| 17 | -232.075377 |
|
| 18 | -179.731443 |
|
| 19 | -110.089036 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12472.256603 |
|
-14201.474955 |
|
| 2 | -2223.116678 |
|
-2717.366824 |
|
| 3 | -770.459545 |
|
-575.574987 |
|
| 4 | -739.123839 |
|
-497.841902 |
|
| 5 | -558.299362 |
|
-289.881051 |
|
| 6 | -460.75359 |
|
-107.48286 |
|
| 7 | -274.685929 |
|
-75.126257 |
|
| 8 | -222.605114 |
|
-66.272866 |
|
| 9 | -215.837448 |
|
-4.762734 |
|
| 10 | -184.630829 |
|
||
| 11 | -152.446965 |
|
||
| 12 | -127.918872 |
|
||
| 13 | -113.290237 |
|
||
| 14 | -75.873998 |
|
||
| 15 | -24.141856 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -16808.606785 |
|
-20089.133372 |
|
| 2 | -3937.002933 |
|
-3638.988367 |
|
| 3 | -1613.905138 |
|
-1252.387591 |
|
| 4 | -644.913925 |
|
-558.550342 |
|
| 5 | -321.407275 |
|
-170.823105 |
|
| 6 | -312.067732 |
|
-98.055235 |
|
| 7 | -219.237114 |
|
-93.790566 |
|
| 8 | -130.7755 |
|
-84.178514 |
|
| 9 | -92.512841 |
|
-68.47071 |
|
| 10 | -88.852016 |
|
-66.283232 |
|
| 11 | -84.377367 |
|
-45.098961 |
|
| 12 | -79.717035 |
|
-37.080301 |
|
| 13 | -72.016721 |
|
-37.080301 |
|
| 14 | -68.554605 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 8.7e-65 |
|
| 3 | 4.5e-56 |
|
| 4 | 4.6e-37 |
|
| 5 | 3e-24 |
|
| 6 | 6.7e-06 |
|
| 7 | 0.31 |
|
| 8 | 1.2 |
|
| 9 | 0.69 |
|
| 10 | 84.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.8e-52 |
|
2.1e-71 |
|
| 3 | 8.9e-32 |
|
1.8e-35 |
|
| 4 | 23000.0 |
|
520000.0 |
|
| 5 | 330.0 |
|
650000.0 |
|
| 6 | 96000.0 |
|
670000.0 |
|
| 7 | 120000.0 |
|
740000.0 |
|
| 8 | 370000.0 |
|
880000.0 |
|
| 9 | 680000.0 |
|
1100000.0 |
|
| 10 | 560000.0 |
|
1200000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.2e-101 |
|
3.2e-102 |
|
| 3 | 1.6e-67 |
|
9.5e-64 |
|
| 4 | 2.1e-27 |
|
8.2e-08 |
|
| 5 | 7000.0 |
|
28.0 |
|
| 6 | 93000.0 |
|
1300.0 |
|
| 7 | 260000.0 |
|
6400.0 |
|
| 8 | 1200000.0 |
|
380000.0 |
|
| 9 | 1200000.0 |
|
820000.0 |
|
| 10 | 1200000.0 |
|
1100000.0 |
|