DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1695 |
|
| 6 | 922 |
|
| 7 | 450 |
|
| 8 | 250 |
|
| 9 | 147 |
|
| 10 | 96 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 10149 |
|
8363 |
|
| 2 | 956 |
|
324 |
|
| 3 | 275 |
|
355 |
|
| 4 | 108 |
|
153 |
|
| 5 | 23 |
|
||
| 6 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 4578 |
|
5219 |
|
| 2 | 684 |
|
869 |
|
| 3 | 170 |
|
225 |
|
| 4 | 5 |
|
9 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5055.181258 |
|
| 2 | -2288.096364 |
|
| 3 | -1326.200135 |
|
| 4 | -1177.587026 |
|
| 5 | -844.485848 |
|
| 6 | -690.247739 |
|
| 7 | -539.123436 |
|
| 8 | -464.63168 |
|
| 9 | -391.120376 |
|
| 10 | -316.030943 |
|
| 11 | -243.367076 |
|
| 12 | -160.487208 |
|
| 13 | -137.706795 |
|
| 14 | -89.913887 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -8743.63136 |
|
-13384.20577 |
|
| 2 | -2664.513356 |
|
-2115.621676 |
|
| 3 | -710.71914 |
|
-638.08505 |
|
| 4 | -497.259148 |
|
-469.000676 |
|
| 5 | -331.363814 |
|
-382.278119 |
|
| 6 | -328.397791 |
|
-187.07289 |
|
| 7 | -323.757187 |
|
-97.826671 |
|
| 8 | -220.043396 |
|
-79.441643 |
|
| 9 | -206.657535 |
|
-56.881382 |
|
| 10 | -103.653269 |
|
-21.994937 |
|
| 11 | -87.124085 |
|
-15.168348 |
|
| 12 | -47.397056 |
|
||
| 13 | -33.547646 |
|
||
| 14 | -31.006115 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -3652.204786 |
|
-3418.07595 |
|
| 2 | -411.170049 |
|
-365.569976 |
|
| 3 | -296.439727 |
|
-342.144969 |
|
| 4 | -262.144938 |
|
-269.066542 |
|
| 5 | -200.965427 |
|
-171.80981 |
|
| 6 | -182.945933 |
|
-143.555449 |
|
| 7 | -167.377638 |
|
-107.747847 |
|
| 8 | -162.265112 |
|
-86.660499 |
|
| 9 | -109.761631 |
|
-68.933194 |
|
| 10 | -76.596268 |
|
-59.93332 |
|
| 11 | -61.086023 |
|
-59.837071 |
|
| 12 | -57.852742 |
|
-56.371046 |
|
| 13 | -56.503943 |
|
-52.949476 |
|
| 14 | -53.588863 |
|
-51.46527 |
|
| 15 | -44.048815 |
|
||
| 16 | -39.75191 |
|
||
| 17 | -13.52644 |
|
||
| 18 | -6.48808 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.1e-154 |
|
| 3 | 3.4e-44 |
|
| 4 | 2.7e-40 |
|
| 5 | 4.9e-20 |
|
| 6 | 5.1e-14 |
|
| 7 | 0.00017 |
|
| 8 | 2e-06 |
|
| 9 | 0.014 |
|
| 10 | 2.8 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9.5e-83 |
|
3.8e-108 |
|
| 3 | 8.8e-46 |
|
5.4e-07 |
|
| 4 | 26000.0 |
|
330.0 |
|
| 5 | 37000.0 |
|
3800.0 |
|
| 6 | 140000.0 |
|
72000.0 |
|
| 7 | 510000.0 |
|
330000.0 |
|
| 8 | 550000.0 |
|
690000.0 |
|
| 9 | 930000.0 |
|
690000.0 |
|
| 10 | 980000.0 |
|
780000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3e-06 |
|
0.0003 |
|
| 3 | 0.00087 |
|
1.7 |
|
| 4 | 21.0 |
|
33000.0 |
|
| 5 | 680.0 |
|
49000.0 |
|
| 6 | 19000.0 |
|
190000.0 |
|
| 7 | 28000.0 |
|
350000.0 |
|
| 8 | 650000.0 |
|
660000.0 |
|
| 9 | 790000.0 |
|
990000.0 |
|
| 10 | 910000.0 |
|
680000.0 |
|