DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 1991 |
|
| 4 | 1558 |
|
| 5 | 866 |
|
| 6 | 539 |
|
| 7 | 376 |
|
| 8 | 357 |
|
| 9 | 321 |
|
| 10 | 298 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 9162 |
|
3755 |
|
| 2 | 1789 |
|
137 |
|
| 3 | 111 |
|
250 |
|
| 4 | 221 |
|
74 |
|
| 5 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7526 |
|
3573 |
|
| 2 | 1403 |
|
576 |
|
| 3 | 137 |
|
58 |
|
| 4 | 24 |
|
12 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2888.096689 |
|
| 2 | -2502.044358 |
|
| 3 | -1155.6236 |
|
| 4 | -1146.45909 |
|
| 5 | -957.858532 |
|
| 6 | -696.015508 |
|
| 7 | -678.014187 |
|
| 8 | -620.973092 |
|
| 9 | -437.282416 |
|
| 10 | -383.611768 |
|
| 11 | -373.346345 |
|
| 12 | -219.743428 |
|
| 13 | -173.496111 |
|
| 14 | -156.957825 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6851.765972 |
|
-7728.662059 |
|
| 2 | -1281.077159 |
|
-590.609363 |
|
| 3 | -517.111762 |
|
-332.649965 |
|
| 4 | -485.419132 |
|
-271.373254 |
|
| 5 | -426.877263 |
|
-81.746698 |
|
| 6 | -346.472012 |
|
-74.414109 |
|
| 7 | -254.85039 |
|
-41.987338 |
|
| 8 | -180.575949 |
|
-18.508181 |
|
| 9 | -179.68136 |
|
||
| 10 | -146.087964 |
|
||
| 11 | -141.788322 |
|
||
| 12 | -138.73089 |
|
||
| 13 | -106.811031 |
|
||
| 14 | -85.592953 |
|
||
| 15 | -69.574818 |
|
||
| 16 | -14.729015 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7617.961797 |
|
-7573.460344 |
|
| 2 | -3299.745475 |
|
-4366.778973 |
|
| 3 | -2039.868085 |
|
-995.884189 |
|
| 4 | -305.305586 |
|
-60.894861 |
|
| 5 | -113.952008 |
|
-42.590053 |
|
| 6 | -107.715349 |
|
||
| 7 | -96.26192 |
|
||
| 8 | -82.009857 |
|
||
| 9 | -80.018778 |
|
||
| 10 | -64.99957 |
|
||
| 11 | -1.550402 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 2e-194 |
|
| 2 | 4.3e-179 |
|
| 3 | 2.1e-41 |
|
| 4 | 3.6e-21 |
|
| 5 | 3.3e-08 |
|
| 6 | 0.022 |
|
| 7 | 0.19 |
|
| 8 | 2.7 |
|
| 9 | 0.71 |
|
| 10 | 120.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5e-37 |
|
2.7e-50 |
|
| 3 | 1e-22 |
|
20.0 |
|
| 4 | 0.00017 |
|
82000.0 |
|
| 5 | 0.021 |
|
190000.0 |
|
| 6 | 120.0 |
|
210000.0 |
|
| 7 | 270.0 |
|
1000000.0 |
|
| 8 | 1600.0 |
|
1000000.0 |
|
| 9 | 12000.0 |
|
840000.0 |
|
| 10 | 39000.0 |
|
1000000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.9e-166 |
|
0.0 |
|
| 3 | 3.8e-43 |
|
5.7e-06 |
|
| 4 | 0.039 |
|
71.0 |
|
| 5 | 16.0 |
|
490000.0 |
|
| 6 | 100000.0 |
|
780000.0 |
|
| 7 | 130000.0 |
|
780000.0 |
|
| 8 | 360000.0 |
|
780000.0 |
|
| 9 | 670000.0 |
|
780000.0 |
|
| 10 | 1000000.0 |
|
850000.0 |
|