DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1999 |
|
| 2 | 1995 |
|
| 3 | 2000 |
|
| 4 | 1991 |
|
| 5 | 1693 |
|
| 6 | 900 |
|
| 7 | 230 |
|
| 8 | 123 |
|
| 9 | 90 |
|
| 10 | 43 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11008 |
|
7728 |
|
| 2 | 723 |
|
269 |
|
| 3 | 308 |
|
377 |
|
| 4 | 124 |
|
147 |
|
| 5 | 28 |
|
19 |
|
| 6 | 3 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7945 |
|
4752 |
|
| 2 | 341 |
|
707 |
|
| 3 | 803 |
|
115 |
|
| 4 | 118 |
|
||
| 5 | 74 |
|
||
| 6 | 29 |
|
||
| 7 | 4 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -5796.539114 |
|
| 2 | -1282.95627 |
|
| 3 | -1116.053768 |
|
| 4 | -1087.998331 |
|
| 5 | -737.488345 |
|
| 6 | -618.505757 |
|
| 7 | -598.656302 |
|
| 8 | -450.593246 |
|
| 9 | -395.692711 |
|
| 10 | -346.378673 |
|
| 11 | -259.373157 |
|
| 12 | -229.738061 |
|
| 13 | -224.896254 |
|
| 14 | -211.230458 |
|
| 15 | -163.21005 |
|
| 16 | -115.24809 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -9221.495495 |
|
-12482.64773 |
|
| 2 | -2553.571187 |
|
-1805.173912 |
|
| 3 | -790.158052 |
|
-540.931077 |
|
| 4 | -508.017189 |
|
-465.681002 |
|
| 5 | -351.339066 |
|
-334.386344 |
|
| 6 | -318.929605 |
|
-166.401149 |
|
| 7 | -224.493263 |
|
-75.609206 |
|
| 8 | -195.779348 |
|
-66.078859 |
|
| 9 | -101.318662 |
|
-40.912384 |
|
| 10 | -62.593103 |
|
||
| 11 | -62.593103 |
|
||
| 12 | -61.67521 |
|
||
| 13 | -54.824558 |
|
||
| 14 | -43.112517 |
|
||
| 15 | -15.436803 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -12163.867542 |
|
-13141.214696 |
|
| 2 | -1363.835301 |
|
-989.045933 |
|
| 3 | -363.459106 |
|
-284.242634 |
|
| 4 | -305.646781 |
|
-196.790222 |
|
| 5 | -100.657927 |
|
-88.172223 |
|
| 6 | -93.376545 |
|
-74.619172 |
|
| 7 | -70.674287 |
|
-69.334185 |
|
| 8 | -61.92072 |
|
-52.998136 |
|
| 9 | -61.92072 |
|
-29.135283 |
|
| 10 | -57.623685 |
|
-6.324026 |
|
| 11 | -22.06008 |
|
||
| 12 | -12.057171 |
|
||
| 13 | -3.663975 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.2e-91 |
|
| 3 | 1.6e-38 |
|
| 4 | 1.5e-11 |
|
| 5 | 0.00017 |
|
| 6 | 0.16 |
|
| 7 | 2.3 |
|
| 8 | 390.0 |
|
| 9 | 280.0 |
|
| 10 | 75000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 4.6e-87 |
|
6.9e-33 |
|
| 3 | 1e-25 |
|
6.9e-33 |
|
| 4 | 3.9e-06 |
|
6.9e-33 |
|
| 5 | 1800.0 |
|
6.9e-33 |
|
| 6 | 3000.0 |
|
6.9e-33 |
|
| 7 | 200000.0 |
|
1.7e-26 |
|
| 8 | 300000.0 |
|
170000.0 |
|
| 9 | 660000.0 |
|
61000.0 |
|
| 10 | 820000.0 |
|
230000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.9e-31 |
|
2.1e-18 |
|
| 3 | 37000.0 |
|
120000.0 |
|
| 4 | 41000.0 |
|
250000.0 |
|
| 5 | 460000.0 |
|
250000.0 |
|
| 6 | 530000.0 |
|
310000.0 |
|
| 7 | 530000.0 |
|
330000.0 |
|
| 8 | 720000.0 |
|
490000.0 |
|
| 9 | 720000.0 |
|
560000.0 |
|
| 10 | 520000.0 |
|
700000.0 |
|