DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 1998 |
|
| 4 | 2000 |
|
| 5 | 1855 |
|
| 6 | 1139 |
|
| 7 | 516 |
|
| 8 | 354 |
|
| 9 | 227 |
|
| 10 | 164 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14628 |
|
17471 |
|
| 2 | 1379 |
|
687 |
|
| 3 | 561 |
|
247 |
|
| 4 | 296 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13787 |
|
15588 |
|
| 2 | 1402 |
|
578 |
|
| 3 | 208 |
|
255 |
|
| 4 | 165 |
|
33 |
|
| 5 | 38 |
|
49 |
|
| 6 | 9 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -11867.875162 |
|
| 2 | -6426.518532 |
|
| 3 | -5542.441758 |
|
| 4 | -4554.311687 |
|
| 5 | -3893.114819 |
|
| 6 | -2899.488554 |
|
| 7 | -2759.842278 |
|
| 8 | -2667.055969 |
|
| 9 | -2619.226088 |
|
| 10 | -2226.707699 |
|
| 11 | -2009.970149 |
|
| 12 | -1748.837949 |
|
| 13 | -1701.426339 |
|
| 14 | -1564.151009 |
|
| 15 | -1121.450013 |
|
| 16 | -979.97127 |
|
| 17 | -914.03736 |
|
| 18 | -620.816743 |
|
| 19 | -410.563368 |
|
| 20 | -200.489974 |
|
| 21 | -162.69011 |
|
| 22 | -108.313779 |
|
| 23 | -47.967617 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -15730.845953 |
|
-22443.377266 |
|
| 2 | -4343.211816 |
|
-3894.621884 |
|
| 3 | -1809.647479 |
|
-1581.395579 |
|
| 4 | -514.620628 |
|
-1394.972598 |
|
| 5 | -351.275615 |
|
-626.888817 |
|
| 6 | -274.809115 |
|
-416.83578 |
|
| 7 | -187.572314 |
|
-343.275546 |
|
| 8 | -139.677196 |
|
-334.858466 |
|
| 9 | -134.769673 |
|
-226.790805 |
|
| 10 | -98.944838 |
|
-162.154442 |
|
| 11 | -87.453674 |
|
-86.7612 |
|
| 12 | -86.807947 |
|
||
| 13 | -36.665745 |
|
||
| 14 | -14.90323 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -14468.530834 |
|
-18640.781443 |
|
| 2 | -4640.393958 |
|
-5380.274751 |
|
| 3 | -3369.26291 |
|
-3989.671673 |
|
| 4 | -706.73935 |
|
-1298.903578 |
|
| 5 | -604.132767 |
|
-484.085047 |
|
| 6 | -458.016856 |
|
-461.371124 |
|
| 7 | -190.365461 |
|
-92.450984 |
|
| 8 | -182.097724 |
|
-23.905486 |
|
| 9 | -144.394793 |
|
-4.852466 |
|
| 10 | -120.346063 |
|
||
| 11 | -118.948297 |
|
||
| 12 | -101.863725 |
|
||
| 13 | -94.266228 |
|
||
| 14 | -2.45391 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 8e-43 |
|
| 3 | 1.3e-23 |
|
| 4 | 1.3e-29 |
|
| 5 | 8.8e-09 |
|
| 6 | 0.0013 |
|
| 7 | 0.00078 |
|
| 8 | 0.57 |
|
| 9 | 2.3 |
|
| 10 | 5.4e-07 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.6e-45 |
|
3.6e-77 |
|
| 3 | 3.7e-09 |
|
0.55 |
|
| 4 | 6.8 |
|
2.3 |
|
| 5 | 28.0 |
|
110000.0 |
|
| 6 | 140.0 |
|
1400000.0 |
|
| 7 | 12000.0 |
|
1800000.0 |
|
| 8 | 140000.0 |
|
1900000.0 |
|
| 9 | 85000.0 |
|
2200000.0 |
|
| 10 | 310000.0 |
|
2500000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.4e-50 |
|
1.8e-64 |
|
| 3 | 8.1e-26 |
|
1.6e-34 |
|
| 4 | 16000.0 |
|
0.003 |
|
| 5 | 72000.0 |
|
540.0 |
|
| 6 | 280000.0 |
|
300000.0 |
|
| 7 | 300000.0 |
|
600000.0 |
|
| 8 | 380000.0 |
|
680000.0 |
|
| 9 | 560000.0 |
|
930000.0 |
|
| 10 | 1000000.0 |
|
1200000.0 |
|