DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1996 |
|
| 5 | 1742 |
|
| 6 | 1026 |
|
| 7 | 513 |
|
| 8 | 260 |
|
| 9 | 147 |
|
| 10 | 110 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15824 |
|
17398 |
|
| 2 | 973 |
|
511 |
|
| 3 | 238 |
|
138 |
|
| 4 | 164 |
|
48 |
|
| 5 | 5 |
|
||
| 6 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15352 |
|
16438 |
|
| 2 | 605 |
|
577 |
|
| 3 | 426 |
|
191 |
|
| 4 | 64 |
|
||
| 5 | 23 |
|
||
| 6 | 7 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -23652.795458 |
|
| 2 | -5958.925063 |
|
| 3 | -5465.478894 |
|
| 4 | -3730.01662 |
|
| 5 | -3517.93092 |
|
| 6 | -3096.655158 |
|
| 7 | -2575.036323 |
|
| 8 | -2344.734403 |
|
| 9 | -2271.279345 |
|
| 10 | -2140.829268 |
|
| 11 | -1935.786129 |
|
| 12 | -1885.32553 |
|
| 13 | -1080.630592 |
|
| 14 | -1046.920564 |
|
| 15 | -878.355912 |
|
| 16 | -747.388109 |
|
| 17 | -627.713427 |
|
| 18 | -243.014529 |
|
| 19 | -212.395056 |
|
| 20 | -117.494908 |
|
| 21 | -116.040481 |
|
| 22 | -111.179683 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19932.461541 |
|
-23511.719331 |
|
| 2 | -3844.590647 |
|
-3727.945954 |
|
| 3 | -1574.877586 |
|
-1150.437292 |
|
| 4 | -447.340932 |
|
-672.677919 |
|
| 5 | -382.313676 |
|
-319.531413 |
|
| 6 | -265.118733 |
|
-318.632225 |
|
| 7 | -213.270972 |
|
-302.991805 |
|
| 8 | -202.403878 |
|
-290.133564 |
|
| 9 | -196.252558 |
|
-175.59731 |
|
| 10 | -161.70464 |
|
-155.305669 |
|
| 11 | -137.538646 |
|
-145.313437 |
|
| 12 | -78.65074 |
|
-69.302757 |
|
| 13 | -75.185904 |
|
||
| 14 | -50.984986 |
|
||
| 15 | -3.270069 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -20307.437433 |
|
-24175.274141 |
|
| 2 | -3316.773197 |
|
-3958.751398 |
|
| 3 | -2545.155752 |
|
-2331.835157 |
|
| 4 | -584.855039 |
|
-1200.52701 |
|
| 5 | -514.286525 |
|
-580.605205 |
|
| 6 | -464.593448 |
|
-267.697199 |
|
| 7 | -420.448587 |
|
-197.353239 |
|
| 8 | -331.653867 |
|
-169.474473 |
|
| 9 | -201.864617 |
|
-145.555679 |
|
| 10 | -201.037804 |
|
-125.879864 |
|
| 11 | -140.022655 |
|
-75.365781 |
|
| 12 | -116.011476 |
|
||
| 13 | -5.501708 |
|
||
| 14 | -1.136466 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.9e-37 |
|
| 3 | 1.7e-18 |
|
| 4 | 4.3e-22 |
|
| 5 | 9.5e-14 |
|
| 6 | 2.2e-06 |
|
| 7 | 0.00027 |
|
| 8 | 0.011 |
|
| 9 | 0.85 |
|
| 10 | 12.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9e-29 |
|
7.3e-21 |
|
| 3 | 15000.0 |
|
550.0 |
|
| 4 | 110000.0 |
|
570.0 |
|
| 5 | 81000.0 |
|
230000.0 |
|
| 6 | 670000.0 |
|
830000.0 |
|
| 7 | 1300000.0 |
|
1000000.0 |
|
| 8 | 560000.0 |
|
1200000.0 |
|
| 9 | 1500000.0 |
|
1600000.0 |
|
| 10 | 2000000.0 |
|
2100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 6e-29 |
|
2e-23 |
|
| 3 | 0.0031 |
|
5.6e-14 |
|
| 4 | 0.13 |
|
0.00099 |
|
| 5 | 3.6 |
|
4300.0 |
|
| 6 | 37.0 |
|
600000.0 |
|
| 7 | 750.0 |
|
950000.0 |
|
| 8 | 1600.0 |
|
2000000.0 |
|
| 9 | 3900.0 |
|
2400000.0 |
|
| 10 | 32000.0 |
|
2500000.0 |
|