DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1986 |
|
| 6 | 1247 |
|
| 7 | 784 |
|
| 8 | 342 |
|
| 9 | 201 |
|
| 10 | 121 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16525 |
|
17252 |
|
| 2 | 746 |
|
592 |
|
| 3 | 394 |
|
219 |
|
| 4 | 33 |
|
||
| 5 | 16 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16296 |
|
16573 |
|
| 2 | 1474 |
|
757 |
|
| 3 | 137 |
|
||
| 4 | 83 |
|
||
| 5 | 17 |
|
||
| 6 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -65411.873747 |
|
| 2 | -9483.701744 |
|
| 3 | -8611.405422 |
|
| 4 | -7920.934027 |
|
| 5 | -6545.645427 |
|
| 6 | -6302.716719 |
|
| 7 | -5949.296885 |
|
| 8 | -5925.012266 |
|
| 9 | -4853.924195 |
|
| 10 | -4647.43947 |
|
| 11 | -4173.820509 |
|
| 12 | -4091.893236 |
|
| 13 | -3925.960625 |
|
| 14 | -3584.033911 |
|
| 15 | -3407.474852 |
|
| 16 | -3192.130137 |
|
| 17 | -3128.329988 |
|
| 18 | -2281.899252 |
|
| 19 | -1427.084043 |
|
| 20 | -173.96874 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -24040.877443 |
|
-27039.446637 |
|
| 2 | -2303.548119 |
|
-2470.535709 |
|
| 3 | -944.233371 |
|
-1099.912002 |
|
| 4 | -931.135206 |
|
-860.594661 |
|
| 5 | -730.856302 |
|
-782.21942 |
|
| 6 | -405.778308 |
|
-738.868079 |
|
| 7 | -379.668853 |
|
-675.978325 |
|
| 8 | -242.381769 |
|
-424.98044 |
|
| 9 | -197.285476 |
|
-270.474167 |
|
| 10 | -151.114639 |
|
-223.825548 |
|
| 11 | -108.62921 |
|
-161.424579 |
|
| 12 | -87.959584 |
|
-147.893239 |
|
| 13 | -33.046119 |
|
-126.552492 |
|
| 14 | -116.853599 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -21930.184701 |
|
-25213.04198 |
|
| 2 | -2359.358787 |
|
-3016.916788 |
|
| 3 | -1398.673815 |
|
-2083.245753 |
|
| 4 | -879.163531 |
|
-1967.005251 |
|
| 5 | -731.897862 |
|
-968.865934 |
|
| 6 | -681.506555 |
|
-823.970306 |
|
| 7 | -363.159511 |
|
-607.130311 |
|
| 8 | -188.657307 |
|
-461.789274 |
|
| 9 | -176.541078 |
|
-381.897524 |
|
| 10 | -168.1895 |
|
-309.966283 |
|
| 11 | -151.126971 |
|
-248.821368 |
|
| 12 | -125.721942 |
|
-176.594994 |
|
| 13 | -63.030637 |
|
-171.46138 |
|
| 14 | -62.393828 |
|
-166.351907 |
|
| 15 | -1.838588 |
|
-157.291183 |
|
| 16 | -116.732734 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.8e-97 |
|
| 3 | 2.4e-77 |
|
| 4 | 1.2e-70 |
|
| 5 | 1.7e-56 |
|
| 6 | 5.8e-24 |
|
| 7 | 2.2e-20 |
|
| 8 | 5.2e-13 |
|
| 9 | 1.2e-08 |
|
| 10 | 0.00028 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.2e-05 |
|
3e-41 |
|
| 3 | 0.00024 |
|
1e-06 |
|
| 4 | 0.068 |
|
0.0005 |
|
| 5 | 2.5 |
|
0.002 |
|
| 6 | 1200.0 |
|
2900.0 |
|
| 7 | 2100.0 |
|
5400.0 |
|
| 8 | 170000.0 |
|
7300.0 |
|
| 9 | 250000.0 |
|
59000.0 |
|
| 10 | 290000.0 |
|
160000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.8e-23 |
|
2.8e-38 |
|
| 3 | 1.8e-13 |
|
2.1e-26 |
|
| 4 | 3.7e-09 |
|
3e-19 |
|
| 5 | 1.1e-07 |
|
5.9e-15 |
|
| 6 | 0.00042 |
|
4.7e-08 |
|
| 7 | 0.011 |
|
0.43 |
|
| 8 | 25000.0 |
|
3.3 |
|
| 9 | 160000.0 |
|
13.0 |
|
| 10 | 220000.0 |
|
110.0 |
|