DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1793 |
|
| 6 | 1005 |
|
| 7 | 442 |
|
| 8 | 109 |
|
| 9 | 28 |
|
| 10 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16080 |
|
17297 |
|
| 2 | 1059 |
|
752 |
|
| 3 | 420 |
|
158 |
|
| 4 | 62 |
|
81 |
|
| 5 | 22 |
|
31 |
|
| 6 | 6 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15562 |
|
16803 |
|
| 2 | 1550 |
|
814 |
|
| 3 | 318 |
|
337 |
|
| 4 | 50 |
|
||
| 5 | 18 |
|
||
| 6 | 3 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -35853.103107 |
|
| 2 | -8940.085059 |
|
| 3 | -7831.480905 |
|
| 4 | -5983.504288 |
|
| 5 | -5806.797123 |
|
| 6 | -4583.46279 |
|
| 7 | -4335.898218 |
|
| 8 | -4246.168662 |
|
| 9 | -3894.066946 |
|
| 10 | -2895.799727 |
|
| 11 | -2499.974831 |
|
| 12 | -1613.890986 |
|
| 13 | -926.856108 |
|
| 14 | -860.266824 |
|
| 15 | -825.177633 |
|
| 16 | -595.401594 |
|
| 17 | -334.317239 |
|
| 18 | -191.696702 |
|
| 19 | -189.500793 |
|
| 20 | -185.935626 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19089.472494 |
|
-21905.114208 |
|
| 2 | -2477.096154 |
|
-3451.764571 |
|
| 3 | -1011.622342 |
|
-2131.869621 |
|
| 4 | -629.256151 |
|
-924.954139 |
|
| 5 | -292.390726 |
|
-475.794498 |
|
| 6 | -182.592292 |
|
-345.15836 |
|
| 7 | -125.266419 |
|
-335.372649 |
|
| 8 | -111.690114 |
|
-124.923119 |
|
| 9 | -101.47076 |
|
-111.269758 |
|
| 10 | -90.713994 |
|
-87.936316 |
|
| 11 | -75.117257 |
|
||
| 12 | -67.401977 |
|
||
| 13 | -2.877383 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -17328.225506 |
|
-20947.538752 |
|
| 2 | -3130.972571 |
|
-3868.877751 |
|
| 3 | -1714.168811 |
|
-1511.294885 |
|
| 4 | -1361.228226 |
|
-1463.535166 |
|
| 5 | -1337.918381 |
|
-926.220498 |
|
| 6 | -546.77141 |
|
-526.246436 |
|
| 7 | -412.277444 |
|
-522.214872 |
|
| 8 | -297.18609 |
|
-453.97953 |
|
| 9 | -257.212764 |
|
-154.322176 |
|
| 10 | -190.877165 |
|
-146.046365 |
|
| 11 | -130.394864 |
|
-129.063708 |
|
| 12 | -111.969161 |
|
-121.695812 |
|
| 13 | -92.405105 |
|
-120.465405 |
|
| 14 | -75.046849 |
|
-98.438366 |
|
| 15 | -72.502391 |
|
-79.259816 |
|
| 16 | -65.538086 |
|
||
| 17 | -32.626433 |
|
||
| 18 | -2.669893 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 4.1e-49 |
|
| 3 | 4.3e-27 |
|
| 4 | 1.9e-16 |
|
| 5 | 1.7e-13 |
|
| 6 | 9.7e-10 |
|
| 7 | 8.5e-08 |
|
| 8 | 7.5e-05 |
|
| 9 | 0.16 |
|
| 10 | 3.6 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 45.0 |
|
1.4e-06 |
|
| 3 | 160.0 |
|
290000.0 |
|
| 4 | 12000.0 |
|
1600000.0 |
|
| 5 | 12000.0 |
|
1900000.0 |
|
| 6 | 190000.0 |
|
2400000.0 |
|
| 7 | 490000.0 |
|
2500000.0 |
|
| 8 | 1100000.0 |
|
2600000.0 |
|
| 9 | 1600000.0 |
|
2400000.0 |
|
| 10 | 1800000.0 |
|
2700000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.7e-33 |
|
2.3e-35 |
|
| 3 | 0.035 |
|
0.025 |
|
| 4 | 610.0 |
|
180000.0 |
|
| 5 | 280000.0 |
|
87000.0 |
|
| 6 | 1800000.0 |
|
220000.0 |
|
| 7 | 2600000.0 |
|
250000.0 |
|
| 8 | 3400000.0 |
|
1000000.0 |
|
| 9 | 3500000.0 |
|
1300000.0 |
|
| 10 | 4000000.0 |
|
1400000.0 |
|