DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1982 |
|
| 5 | 1545 |
|
| 6 | 866 |
|
| 7 | 454 |
|
| 8 | 210 |
|
| 9 | 175 |
|
| 10 | 111 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 7409 |
|
4095 |
|
| 2 | 5085 |
|
3561 |
|
| 3 | 1017 |
|
||
| 4 | 154 |
|
||
| 5 | 69 |
|
||
| 6 | 4 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6171 |
|
5091 |
|
| 2 | 5134 |
|
2485 |
|
| 3 | 11 |
|
770 |
|
| 4 | 3 |
|
77 |
|
| 5 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -2635.615793 |
|
| 2 | -1509.279936 |
|
| 3 | -1419.395957 |
|
| 4 | -1298.391373 |
|
| 5 | -1278.706023 |
|
| 6 | -1275.789162 |
|
| 7 | -1245.173972 |
|
| 8 | -1126.922754 |
|
| 9 | -997.473608 |
|
| 10 | -753.822894 |
|
| 11 | -741.673412 |
|
| 12 | -706.703986 |
|
| 13 | -652.776728 |
|
| 14 | -581.487915 |
|
| 15 | -533.419139 |
|
| 16 | -428.922491 |
|
| 17 | -242.176649 |
|
| 18 | -197.716616 |
|
| 19 | -142.085091 |
|
| 20 | -138.139903 |
|
| 21 | -88.691117 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7293.711453 |
|
-9295.756484 |
|
| 2 | -4200.633592 |
|
-5121.519464 |
|
| 3 | -686.550938 |
|
-604.405139 |
|
| 4 | -572.174209 |
|
-445.648058 |
|
| 5 | -519.044518 |
|
-231.099684 |
|
| 6 | -140.995434 |
|
-198.427441 |
|
| 7 | -137.638139 |
|
-172.763612 |
|
| 8 | -124.173297 |
|
-98.669155 |
|
| 9 | -101.580723 |
|
-94.026769 |
|
| 10 | -96.598105 |
|
-80.195396 |
|
| 11 | -90.636016 |
|
-58.065015 |
|
| 12 | -89.472007 |
|
-27.541205 |
|
| 13 | -53.864792 |
|
||
| 14 | -41.100497 |
|
||
| 15 | -34.199865 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7178.694602 |
|
-8633.242077 |
|
| 2 | -4084.276781 |
|
-4888.233779 |
|
| 3 | -492.053151 |
|
-521.266671 |
|
| 4 | -447.259539 |
|
-363.937722 |
|
| 5 | -206.893439 |
|
-218.589822 |
|
| 6 | -173.079242 |
|
-193.201465 |
|
| 7 | -170.466324 |
|
-132.092754 |
|
| 8 | -146.369197 |
|
-127.363724 |
|
| 9 | -142.567336 |
|
-96.47171 |
|
| 10 | -137.261427 |
|
-88.817603 |
|
| 11 | -113.076095 |
|
-72.78293 |
|
| 12 | -68.115248 |
|
-57.404365 |
|
| 13 | -66.521716 |
|
-52.8959 |
|
| 14 | -63.518476 |
|
-46.376447 |
|
| 15 | -32.903092 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.3e-49 |
|
| 2 | 1.9e-17 |
|
| 3 | 2.2e-12 |
|
| 4 | 1.4e-09 |
|
| 5 | 8.9e-05 |
|
| 6 | 6.5 |
|
| 7 | 4000.0 |
|
| 8 | 4100.0 |
|
| 9 | 160000.0 |
|
| 10 | 130000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2.3e-197 |
|
0.0 |
|
| 2 | 2.5e-144 |
|
5.5e-282 |
|
| 3 | 3e-41 |
|
530.0 |
|
| 4 | 1.3e-15 |
|
70000.0 |
|
| 5 | 55.0 |
|
16000.0 |
|
| 6 | 1400.0 |
|
160000.0 |
|
| 7 | 1400.0 |
|
580000.0 |
|
| 8 | 15000.0 |
|
880000.0 |
|
| 9 | 65000.0 |
|
830000.0 |
|
| 10 | 14000.0 |
|
830000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 8.2e-211 |
|
0.0 |
|
| 2 | 2.4e-136 |
|
1.6e-234 |
|
| 3 | 1.9e-78 |
|
330.0 |
|
| 4 | 9.7e-09 |
|
9500.0 |
|
| 5 | 1.3e-06 |
|
15000.0 |
|
| 6 | 120000.0 |
|
480000.0 |
|
| 7 | 170000.0 |
|
530000.0 |
|
| 8 | 83000.0 |
|
900000.0 |
|
| 9 | 170000.0 |
|
810000.0 |
|
| 10 | 310000.0 |
|
810000.0 |
|