DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1952 |
|
| 5 | 1279 |
|
| 6 | 635 |
|
| 7 | 285 |
|
| 8 | 122 |
|
| 9 | 46 |
|
| 10 | 18 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12649 |
|
4751 |
|
| 2 | 1365 |
|
6042 |
|
| 3 | 274 |
|
343 |
|
| 4 | 103 |
|
147 |
|
| 5 | 28 |
|
11 |
|
| 6 | 7 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12115 |
|
5623 |
|
| 2 | 2025 |
|
4095 |
|
| 3 | 142 |
|
733 |
|
| 4 | 41 |
|
343 |
|
| 5 | 122 |
|
||
| 6 | 67 |
|
||
| 7 | 6 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -4997.449793 |
|
| 2 | -3791.728865 |
|
| 3 | -3746.933508 |
|
| 4 | -2695.516904 |
|
| 5 | -2216.550379 |
|
| 6 | -1838.652685 |
|
| 7 | -1708.930489 |
|
| 8 | -1634.62743 |
|
| 9 | -1485.087155 |
|
| 10 | -1413.44767 |
|
| 11 | -1389.958905 |
|
| 12 | -1150.464314 |
|
| 13 | -973.48986 |
|
| 14 | -886.044754 |
|
| 15 | -860.349684 |
|
| 16 | -827.665481 |
|
| 17 | -677.969876 |
|
| 18 | -306.33524 |
|
| 19 | -211.998999 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -7655.127044 |
|
-14125.814292 |
|
| 2 | -4710.254194 |
|
-8613.199302 |
|
| 3 | -774.75216 |
|
-1170.736041 |
|
| 4 | -644.636212 |
|
-633.130057 |
|
| 5 | -498.22453 |
|
-414.473098 |
|
| 6 | -317.238473 |
|
-275.557149 |
|
| 7 | -199.764496 |
|
-182.808861 |
|
| 8 | -152.701322 |
|
-177.638316 |
|
| 9 | -147.578374 |
|
-105.625994 |
|
| 10 | -104.552596 |
|
-98.748639 |
|
| 11 | -53.900918 |
|
-91.761869 |
|
| 12 | -50.212171 |
|
-84.482188 |
|
| 13 | -49.656907 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -6017.584646 |
|
-15460.414226 |
|
| 2 | -4341.423 |
|
-8096.319463 |
|
| 3 | -632.201676 |
|
-794.215081 |
|
| 4 | -605.533891 |
|
-622.074699 |
|
| 5 | -519.888207 |
|
-446.575314 |
|
| 6 | -453.925198 |
|
-219.137651 |
|
| 7 | -412.310805 |
|
-93.814852 |
|
| 8 | -325.892463 |
|
-84.569636 |
|
| 9 | -325.588068 |
|
-46.367088 |
|
| 10 | -217.818761 |
|
-0.262308 |
|
| 11 | -153.385761 |
|
||
| 12 | -148.880654 |
|
||
| 13 | -117.97356 |
|
||
| 14 | -60.049761 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 1.1e-86 |
|
| 2 | 1.2e-54 |
|
| 3 | 8.1e-39 |
|
| 4 | 1.7e-17 |
|
| 5 | 1.9e-14 |
|
| 6 | 4.3e-14 |
|
| 7 | 7.7e-05 |
|
| 8 | 140.0 |
|
| 9 | 3100.0 |
|
| 10 | 4700.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 6.6e-170 |
|
0.0 |
|
| 2 | 2.7e-153 |
|
3.7e-188 |
|
| 3 | 2.3e-05 |
|
1.6e-15 |
|
| 4 | 42.0 |
|
1100.0 |
|
| 5 | 120.0 |
|
220000.0 |
|
| 6 | 32000.0 |
|
940000.0 |
|
| 7 | 29000.0 |
|
1100000.0 |
|
| 8 | 60000.0 |
|
1100000.0 |
|
| 9 | 10000.0 |
|
1400000.0 |
|
| 10 | 540000.0 |
|
2100000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 3.1e-159 |
|
0.0 |
|
| 2 | 1.9e-127 |
|
2.8e-231 |
|
| 3 | 4.4e-11 |
|
0.0038 |
|
| 4 | 1e-06 |
|
210000.0 |
|
| 5 | 4300.0 |
|
820000.0 |
|
| 6 | 62000.0 |
|
1100000.0 |
|
| 7 | 410000.0 |
|
1100000.0 |
|
| 8 | 690000.0 |
|
1300000.0 |
|
| 9 | 750000.0 |
|
1200000.0 |
|
| 10 | 510000.0 |
|
1100000.0 |
|