DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 2000 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1986 |
|
| 5 | 1472 |
|
| 6 | 1028 |
|
| 7 | 425 |
|
| 8 | 220 |
|
| 9 | 128 |
|
| 10 | 88 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 2855 |
|
1742 |
|
| 2 | 1046 |
|
155 |
|
| 3 | 22 |
|
39 |
|
| 4 | 6 |
|
17 |
|
| 5 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 1059 |
|
1368 |
|
| 2 | 808 |
|
270 |
|
| 3 | 98 |
|
79 |
|
| 4 | 14 |
|
||
| 5 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -3314.835237 |
|
| 2 | -353.873812 |
|
| 3 | -343.280537 |
|
| 4 | -282.920608 |
|
| 5 | -211.743936 |
|
| 6 | -203.124994 |
|
| 7 | -202.708597 |
|
| 8 | -160.260009 |
|
| 9 | -159.202705 |
|
| 10 | -146.517778 |
|
| 11 | -143.927645 |
|
| 12 | -143.927645 |
|
| 13 | -138.892058 |
|
| 14 | -133.885845 |
|
| 15 | -128.909869 |
|
| 16 | -128.766953 |
|
| 17 | -126.23465 |
|
| 18 | -124.259742 |
|
| 19 | -101.98136 |
|
| 20 | -98.478505 |
|
| 21 | -77.147491 |
|
| 22 | -71.620414 |
|
| 23 | -69.738069 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -4540.904516 |
|
-4822.352898 |
|
| 2 | -545.059932 |
|
-768.599209 |
|
| 3 | -355.569661 |
|
-360.450166 |
|
| 4 | -352.237121 |
|
-286.441727 |
|
| 5 | -315.642752 |
|
-179.721463 |
|
| 6 | -312.44184 |
|
-149.382404 |
|
| 7 | -267.933056 |
|
-149.382404 |
|
| 8 | -256.963479 |
|
-105.76776 |
|
| 9 | -229.853298 |
|
-78.253565 |
|
| 10 | -224.556688 |
|
-55.550292 |
|
| 11 | -161.754151 |
|
-13.367944 |
|
| 12 | -148.255986 |
|
||
| 13 | -146.607978 |
|
||
| 14 | -130.57691 |
|
||
| 15 | -104.859646 |
|
||
| 16 | -70.673003 |
|
||
| 17 | -69.405072 |
|
||
| 18 | -57.61941 |
|
||
| 19 | -51.550801 |
|
||
| 20 | -39.404979 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -180.664938 |
|
-153.703172 |
|
| 2 | -165.547719 |
|
-99.47049 |
|
| 3 | -124.878626 |
|
-90.605554 |
|
| 4 | -80.093428 |
|
-84.890647 |
|
| 5 | -72.305195 |
|
-84.88425 |
|
| 6 | -54.675111 |
|
-76.25888 |
|
| 7 | -50.41176 |
|
-72.002006 |
|
| 8 | -44.28344 |
|
-71.749577 |
|
| 9 | -43.901422 |
|
-71.749577 |
|
| 10 | -40.225597 |
|
-60.590431 |
|
| 11 | -38.029081 |
|
-55.623799 |
|
| 12 | -36.719339 |
|
-54.23057 |
|
| 13 | -23.440207 |
|
-46.85494 |
|
| 14 | -7.459285 |
|
-39.814875 |
|
| 15 | -4.270201 |
|
-39.814875 |
|
| 16 | -32.702775 |
|
||
| 17 | -22.467125 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 3.5e-72 |
|
| 3 | 3.7e-65 |
|
| 4 | 2.3e-50 |
|
| 5 | 4.1e-34 |
|
| 6 | 8.6e-36 |
|
| 7 | 4.8e-29 |
|
| 8 | 1e-19 |
|
| 9 | 4.1e-17 |
|
| 10 | 2e-07 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.1e-69 |
|
1.9e-73 |
|
| 3 | 4.4e-45 |
|
3.7e-07 |
|
| 4 | 1.7e-40 |
|
0.011 |
|
| 5 | 5.4e-30 |
|
1500.0 |
|
| 6 | 6e-26 |
|
2500.0 |
|
| 7 | 2.7e-24 |
|
3300.0 |
|
| 8 | 7.3e-12 |
|
88000.0 |
|
| 9 | 6.8e-09 |
|
1800000.0 |
|
| 10 | 3.6e-05 |
|
2600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
5.5e-106 |
|
| 2 | 2.4e-215 |
|
1.9e-43 |
|
| 3 | 1e-17 |
|
2.6e-41 |
|
| 4 | 1.2e-07 |
|
9.5e-41 |
|
| 5 | 0.83 |
|
1.1e-13 |
|
| 6 | 3.3 |
|
2.8e-05 |
|
| 7 | 5800.0 |
|
1.8 |
|
| 8 | 280000.0 |
|
35.0 |
|
| 9 | 130000.0 |
|
0.019 |
|
| 10 | 950000.0 |
|
25.0 |
|