DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1532 |
|
| 2 | 1999 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1994 |
|
| 6 | 1573 |
|
| 7 | 806 |
|
| 8 | 385 |
|
| 9 | 210 |
|
| 10 | 93 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13451 |
|
16163 |
|
| 2 | 1271 |
|
863 |
|
| 3 | 1770 |
|
562 |
|
| 4 | 461 |
|
||
| 5 | 174 |
|
||
| 6 | 45 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13934 |
|
15305 |
|
| 2 | 3498 |
|
1055 |
|
| 3 | 129 |
|
||
| 4 | 302 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -70819.268534 |
|
| 2 | -13904.670864 |
|
| 3 | -11347.363051 |
|
| 4 | -9034.936024 |
|
| 5 | -8306.133168 |
|
| 6 | -8069.780233 |
|
| 7 | -7652.101721 |
|
| 8 | -7634.068302 |
|
| 9 | -7119.891098 |
|
| 10 | -6870.945336 |
|
| 11 | -4410.145441 |
|
| 12 | -3573.767699 |
|
| 13 | -2236.461197 |
|
| 14 | -1448.095098 |
|
| 15 | -1415.69731 |
|
| 16 | -1114.948278 |
|
| 17 | -1088.606344 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -28465.925824 |
|
-40243.331162 |
|
| 2 | -6446.546424 |
|
-6470.162206 |
|
| 3 | -4667.6508 |
|
-2874.149127 |
|
| 4 | -4143.277686 |
|
-1420.52316 |
|
| 5 | -4104.235977 |
|
-1281.627623 |
|
| 6 | -3494.864653 |
|
-933.302096 |
|
| 7 | -2852.552531 |
|
-843.550217 |
|
| 8 | -2434.609289 |
|
-757.535337 |
|
| 9 | -2193.863831 |
|
-610.22074 |
|
| 10 | -2115.597467 |
|
-571.480735 |
|
| 11 | -2063.860127 |
|
-156.781897 |
|
| 12 | -1367.404934 |
|
-110.668042 |
|
| 13 | -1138.2927 |
|
-52.314306 |
|
| 14 | -1111.613699 |
|
-36.724315 |
|
| 15 | -924.747931 |
|
-14.899709 |
|
| 16 | -875.422768 |
|
||
| 17 | -843.225306 |
|
||
| 18 | -628.878806 |
|
||
| 19 | -456.107752 |
|
||
| 20 | -435.319783 |
|
||
| 21 | -96.118514 |
|
||
| 22 | -52.821903 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -30109.216637 |
|
-35859.573015 |
|
| 2 | -6839.468153 |
|
-6595.216491 |
|
| 3 | -4478.224242 |
|
-4197.25633 |
|
| 4 | -3157.637062 |
|
-4122.619492 |
|
| 5 | -2884.012193 |
|
-3602.471334 |
|
| 6 | -2005.136891 |
|
-1690.873136 |
|
| 7 | -1504.764927 |
|
-1554.289057 |
|
| 8 | -1336.068082 |
|
-1082.438737 |
|
| 9 | -1164.263081 |
|
-564.268161 |
|
| 10 | -972.261974 |
|
-511.764253 |
|
| 11 | -772.412052 |
|
-447.146651 |
|
| 12 | -696.780319 |
|
-175.463769 |
|
| 13 | -622.412767 |
|
-82.512563 |
|
| 14 | -512.075473 |
|
-49.11947 |
|
| 15 | -506.894285 |
|
-25.2809 |
|
| 16 | -412.237421 |
|
||
| 17 | -381.337869 |
|
||
| 18 | -75.348004 |
|
||
| 19 | -32.755835 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 0.0 |
|
| 3 | 1e-252 |
|
| 4 | 7.8e-202 |
|
| 5 | 2.2e-74 |
|
| 6 | 4.1e-54 |
|
| 7 | 1.7e-53 |
|
| 8 | 3.5e-28 |
|
| 9 | 4.4e-21 |
|
| 10 | 6.6e-13 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.9e-177 |
|
9.2e-92 |
|
| 3 | 5e-111 |
|
9.8e-77 |
|
| 4 | 1.5e-81 |
|
1.3e-38 |
|
| 5 | 1.3e-42 |
|
8.6e-18 |
|
| 6 | 1.4e-33 |
|
1.7e-15 |
|
| 7 | 2.5e-23 |
|
0.0066 |
|
| 8 | 2.9e-20 |
|
73.0 |
|
| 9 | 1.7e-16 |
|
180.0 |
|
| 10 | 8.8e-15 |
|
520.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5.6e-171 |
|
2.1e-114 |
|
| 3 | 6.8e-102 |
|
7.6e-35 |
|
| 4 | 9e-38 |
|
2.8e-30 |
|
| 5 | 1.2e-30 |
|
1.2e-19 |
|
| 6 | 1.4e-14 |
|
4.9e-06 |
|
| 7 | 4.4e-12 |
|
0.05 |
|
| 8 | 2.4e-09 |
|
0.15 |
|
| 9 | 4.8e-08 |
|
890.0 |
|
| 10 | 2.4e-05 |
|
20000.0 |
|