DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1641 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1957 |
|
| 6 | 1103 |
|
| 7 | 621 |
|
| 8 | 412 |
|
| 9 | 254 |
|
| 10 | 193 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 12589 |
|
13064 |
|
| 2 | 1903 |
|
2306 |
|
| 3 | 1168 |
|
456 |
|
| 4 | 274 |
|
||
| 5 | 41 |
|
||
| 6 | 22 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13005 |
|
11701 |
|
| 2 | 2509 |
|
1941 |
|
| 3 | 1109 |
|
569 |
|
| 4 | 200 |
|
||
| 5 | 85 |
|
||
| 6 | 68 |
|
||
| 7 | 1 |
|
||
| 8 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -87577.171884 |
|
| 2 | -13564.938376 |
|
| 3 | -9476.446898 |
|
| 4 | -9106.368366 |
|
| 5 | -7854.77239 |
|
| 6 | -7736.044125 |
|
| 7 | -5457.542081 |
|
| 8 | -4574.998578 |
|
| 9 | -2984.373834 |
|
| 10 | -2772.401893 |
|
| 11 | -2307.776127 |
|
| 12 | -1874.651718 |
|
| 13 | -1772.516369 |
|
| 14 | -1587.776235 |
|
| 15 | -1482.818174 |
|
| 16 | -1350.308679 |
|
| 17 | -1347.86675 |
|
| 18 | -1296.684391 |
|
| 19 | -388.544702 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -26398.398415 |
|
-30947.871192 |
|
| 2 | -5289.141918 |
|
-7332.044372 |
|
| 3 | -1879.650044 |
|
-1202.44366 |
|
| 4 | -1163.303591 |
|
-1116.440734 |
|
| 5 | -790.789144 |
|
-607.606637 |
|
| 6 | -458.709053 |
|
-429.265032 |
|
| 7 | -431.225663 |
|
-389.600278 |
|
| 8 | -400.235491 |
|
-366.60358 |
|
| 9 | -352.244227 |
|
-248.434465 |
|
| 10 | -337.312754 |
|
-155.195234 |
|
| 11 | -321.103175 |
|
||
| 12 | -248.867872 |
|
||
| 13 | -232.756451 |
|
||
| 14 | -190.645293 |
|
||
| 15 | -144.977499 |
|
||
| 16 | -133.193877 |
|
||
| 17 | -125.366358 |
|
||
| 18 | -98.863253 |
|
||
| 19 | -48.551881 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -28919.739838 |
|
-25521.836063 |
|
| 2 | -5892.086018 |
|
-7192.917824 |
|
| 3 | -1289.499762 |
|
-959.400117 |
|
| 4 | -778.800361 |
|
-638.675534 |
|
| 5 | -376.316142 |
|
-529.34002 |
|
| 6 | -367.12534 |
|
-451.980291 |
|
| 7 | -354.001161 |
|
-429.568293 |
|
| 8 | -352.847593 |
|
-260.473809 |
|
| 9 | -246.459505 |
|
-115.472658 |
|
| 10 | -133.031062 |
|
-96.663751 |
|
| 11 | -128.702189 |
|
-68.597419 |
|
| 12 | -49.306149 |
|
-38.263147 |
|
| 13 | -39.174723 |
|
-34.788447 |
|
| 14 | -14.937728 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.6e-101 |
|
| 3 | 2.6e-42 |
|
| 4 | 1.3e-30 |
|
| 5 | 1.7e-27 |
|
| 6 | 1.3e-26 |
|
| 7 | 2.5e-18 |
|
| 8 | 1e-06 |
|
| 9 | 0.0012 |
|
| 10 | 8.6e-07 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.9e-99 |
|
1.3e-211 |
|
| 3 | 1.2e-24 |
|
6e-14 |
|
| 4 | 6.6e-10 |
|
7.2e-05 |
|
| 5 | 0.00074 |
|
0.0017 |
|
| 6 | 4.0 |
|
7700.0 |
|
| 7 | 22.0 |
|
10000.0 |
|
| 8 | 12.0 |
|
130000.0 |
|
| 9 | 1900.0 |
|
100000.0 |
|
| 10 | 12000.0 |
|
600000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.6e-107 |
|
1e-169 |
|
| 3 | 0.004 |
|
2.8e-17 |
|
| 4 | 7600.0 |
|
2000.0 |
|
| 5 | 20000.0 |
|
49000.0 |
|
| 6 | 33000.0 |
|
90000.0 |
|
| 7 | 68000.0 |
|
130000.0 |
|
| 8 | 83000.0 |
|
160000.0 |
|
| 9 | 440000.0 |
|
270000.0 |
|
| 10 | 890000.0 |
|
500000.0 |
|