DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1577 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 1999 |
|
| 5 | 1769 |
|
| 6 | 901 |
|
| 7 | 694 |
|
| 8 | 400 |
|
| 9 | 249 |
|
| 10 | 249 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15354 |
|
17148 |
|
| 2 | 1394 |
|
1082 |
|
| 3 | 690 |
|
362 |
|
| 4 | 54 |
|
||
| 5 | 8 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 15356 |
|
12634 |
|
| 2 | 1629 |
|
1199 |
|
| 3 | 139 |
|
255 |
|
| 4 | 30 |
|
68 |
|
| 5 | 12 |
|
6 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -76846.445585 |
|
| 2 | -7449.309446 |
|
| 3 | -6402.423912 |
|
| 4 | -6264.732817 |
|
| 5 | -6004.336598 |
|
| 6 | -5347.679768 |
|
| 7 | -4967.286299 |
|
| 8 | -4569.505659 |
|
| 9 | -3749.946262 |
|
| 10 | -3415.924483 |
|
| 11 | -2639.549181 |
|
| 12 | -2466.846139 |
|
| 13 | -2014.911413 |
|
| 14 | -929.074398 |
|
| 15 | -923.311104 |
|
| 16 | -922.409886 |
|
| 17 | -817.799644 |
|
| 18 | -571.100601 |
|
| 19 | -365.865907 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -31711.431625 |
|
-41500.832462 |
|
| 2 | -3274.478126 |
|
-3472.096536 |
|
| 3 | -1226.981796 |
|
-1779.447691 |
|
| 4 | -801.186508 |
|
-1107.030314 |
|
| 5 | -782.167796 |
|
-681.431937 |
|
| 6 | -639.985379 |
|
-639.393655 |
|
| 7 | -572.500459 |
|
-513.404409 |
|
| 8 | -572.500459 |
|
-460.193498 |
|
| 9 | -544.0219 |
|
-418.976603 |
|
| 10 | -533.349416 |
|
-283.595424 |
|
| 11 | -452.657055 |
|
-266.879679 |
|
| 12 | -365.591314 |
|
-253.296352 |
|
| 13 | -348.511539 |
|
-247.907187 |
|
| 14 | -337.729319 |
|
-164.343503 |
|
| 15 | -327.588687 |
|
-134.532251 |
|
| 16 | -317.497942 |
|
-105.771074 |
|
| 17 | -309.139189 |
|
-82.775239 |
|
| 18 | -211.456734 |
|
||
| 19 | -14.952453 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -36851.249372 |
|
-45432.455729 |
|
| 2 | -1925.830962 |
|
-2701.893164 |
|
| 3 | -1618.225032 |
|
-1960.319574 |
|
| 4 | -1307.139226 |
|
-1791.279664 |
|
| 5 | -569.17636 |
|
-1024.0215 |
|
| 6 | -414.702202 |
|
-731.032379 |
|
| 7 | -331.173915 |
|
-301.07776 |
|
| 8 | -313.476129 |
|
-297.121358 |
|
| 9 | -200.112249 |
|
-261.008521 |
|
| 10 | -118.27443 |
|
-221.505502 |
|
| 11 | -69.402484 |
|
-217.00074 |
|
| 12 | -13.66087 |
|
-135.716043 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 7.9e-134 |
|
| 3 | 2.1e-149 |
|
| 4 | 3.1e-57 |
|
| 5 | 4e-43 |
|
| 6 | 2.3e-35 |
|
| 7 | 7.7e-29 |
|
| 8 | 5.8e-16 |
|
| 9 | 2.7e-14 |
|
| 10 | 2.3e-05 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 9.1e-77 |
|
8.2e-37 |
|
| 3 | 2.2e-25 |
|
7.8e-20 |
|
| 4 | 1.1e-11 |
|
1.4e-08 |
|
| 5 | 9.1e-08 |
|
9.2 |
|
| 6 | 2.3e-05 |
|
15.0 |
|
| 7 | 0.00046 |
|
1100.0 |
|
| 8 | 4.9 |
|
1900.0 |
|
| 9 | 1600.0 |
|
480000.0 |
|
| 10 | 2700.0 |
|
540000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 7.3e-35 |
|
5.3e-53 |
|
| 3 | 1.1e-18 |
|
1.6e-28 |
|
| 4 | 390.0 |
|
7e-08 |
|
| 5 | 200000.0 |
|
480.0 |
|
| 6 | 540000.0 |
|
260000.0 |
|
| 7 | 71000.0 |
|
570000.0 |
|
| 8 | 570000.0 |
|
1100000.0 |
|
| 9 | 960000.0 |
|
1200000.0 |
|
| 10 | 1600000.0 |
|
1500000.0 |
|