DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1314 |
|
| 2 | 2000 |
|
| 3 | 1998 |
|
| 4 | 1705 |
|
| 5 | 1036 |
|
| 6 | 582 |
|
| 7 | 302 |
|
| 8 | 211 |
|
| 9 | 138 |
|
| 10 | 77 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14958 |
|
15531 |
|
| 2 | 2507 |
|
1054 |
|
| 3 | 309 |
|
||
| 4 | 144 |
|
||
| 5 | 25 |
|
||
| 6 | 1 |
|
||
| 7 | 1 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 16827 |
|
16032 |
|
| 2 | 1183 |
|
446 |
|
| 3 | 80 |
|
||
| 4 | 27 |
|
||
| 5 | 4 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -72285.162494 |
|
| 2 | -5437.863213 |
|
| 3 | -5133.4985 |
|
| 4 | -4723.54962 |
|
| 5 | -4615.498685 |
|
| 6 | -3926.067942 |
|
| 7 | -3867.34369 |
|
| 8 | -3824.130888 |
|
| 9 | -3405.841089 |
|
| 10 | -2313.196114 |
|
| 11 | -2113.425068 |
|
| 12 | -1890.764528 |
|
| 13 | -1702.527173 |
|
| 14 | -1532.722722 |
|
| 15 | -1271.587278 |
|
| 16 | -1112.82814 |
|
| 17 | -1066.509636 |
|
| 18 | -1056.303765 |
|
| 19 | -822.057343 |
|
| 20 | -733.473188 |
|
| 21 | -456.408732 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -31781.431594 |
|
-33582.836768 |
|
| 2 | -2720.736362 |
|
-3850.870215 |
|
| 3 | -1999.887819 |
|
-1288.867135 |
|
| 4 | -1506.294403 |
|
-1232.057306 |
|
| 5 | -1239.483626 |
|
-779.161649 |
|
| 6 | -1138.701267 |
|
-660.628966 |
|
| 7 | -1107.8519 |
|
-585.734574 |
|
| 8 | -973.296304 |
|
-537.319384 |
|
| 9 | -914.436521 |
|
-209.254185 |
|
| 10 | -752.135754 |
|
-173.618627 |
|
| 11 | -567.780892 |
|
-170.409318 |
|
| 12 | -476.544151 |
|
-137.709572 |
|
| 13 | -406.921062 |
|
-130.470009 |
|
| 14 | -302.429797 |
|
||
| 15 | -268.670148 |
|
||
| 16 | -74.425814 |
|
||
| 17 | -70.008644 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -35757.710958 |
|
-34662.923767 |
|
| 2 | -2777.94493 |
|
-3781.982752 |
|
| 3 | -855.317783 |
|
-939.916737 |
|
| 4 | -511.958475 |
|
-753.647213 |
|
| 5 | -482.762937 |
|
-404.923278 |
|
| 6 | -383.215862 |
|
-336.336486 |
|
| 7 | -259.911046 |
|
-332.439449 |
|
| 8 | -191.820257 |
|
-154.783111 |
|
| 9 | -155.388009 |
|
-131.208403 |
|
| 10 | -58.380143 |
|
-111.163312 |
|
| 11 | -52.744749 |
|
-101.726684 |
|
| 12 | -38.4482 |
|
-56.989532 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 3.4e-169 |
|
| 3 | 1.5e-105 |
|
| 4 | 1.2e-63 |
|
| 5 | 2.2e-54 |
|
| 6 | 8.4e-28 |
|
| 7 | 6.6e-24 |
|
| 8 | 1.1e-21 |
|
| 9 | 1.3e-18 |
|
| 10 | 3.7e-16 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.5e-83 |
|
1.4e-70 |
|
| 3 | 1.2e-56 |
|
6.3e-20 |
|
| 4 | 2.3e-45 |
|
7.5e-20 |
|
| 5 | 4.1e-33 |
|
1.7e-09 |
|
| 6 | 3.6e-25 |
|
27000.0 |
|
| 7 | 9.3e-18 |
|
220000.0 |
|
| 8 | 2.7e-16 |
|
96000.0 |
|
| 9 | 2.2e-16 |
|
400000.0 |
|
| 10 | 7.7e-06 |
|
1400000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 3.9e-26 |
|
4.2e-80 |
|
| 3 | 2.5e-13 |
|
3.1e-13 |
|
| 4 | 150.0 |
|
2.2e-08 |
|
| 5 | 28000.0 |
|
0.00034 |
|
| 6 | 39000.0 |
|
4100.0 |
|
| 7 | 120000.0 |
|
5200.0 |
|
| 8 | 1300000.0 |
|
26000.0 |
|
| 9 | 2100000.0 |
|
240000.0 |
|
| 10 | 2200000.0 |
|
620000.0 |
|