DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1395 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1917 |
|
| 6 | 1202 |
|
| 7 | 738 |
|
| 8 | 471 |
|
| 9 | 226 |
|
| 10 | 145 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 11473 |
|
14254 |
|
| 2 | 4287 |
|
1680 |
|
| 3 | 175 |
|
942 |
|
| 4 | 355 |
|
461 |
|
| 5 | 125 |
|
||
| 6 | 58 |
|
||
| 7 | 5 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13141 |
|
13524 |
|
| 2 | 1921 |
|
2666 |
|
| 3 | 1835 |
|
639 |
|
| 4 | 350 |
|
||
| 5 | 25 |
|
||
| 6 | 5 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -18945.014176 |
|
| 2 | -4961.534705 |
|
| 3 | -4086.839961 |
|
| 4 | -3298.971219 |
|
| 5 | -3162.869139 |
|
| 6 | -2979.384357 |
|
| 7 | -2559.498025 |
|
| 8 | -2484.596978 |
|
| 9 | -2286.79765 |
|
| 10 | -1918.874467 |
|
| 11 | -1801.437202 |
|
| 12 | -1799.706339 |
|
| 13 | -1430.432981 |
|
| 14 | -1339.218653 |
|
| 15 | -1313.957315 |
|
| 16 | -1057.977153 |
|
| 17 | -616.585709 |
|
| 18 | -317.138945 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19284.331087 |
|
-30313.730254 |
|
| 2 | -4534.977418 |
|
-3222.791269 |
|
| 3 | -4350.971249 |
|
-2757.385169 |
|
| 4 | -3235.564156 |
|
-2712.710637 |
|
| 5 | -3167.177654 |
|
-1529.635453 |
|
| 6 | -2343.000424 |
|
-1434.866734 |
|
| 7 | -2226.680527 |
|
-747.85174 |
|
| 8 | -2077.301321 |
|
-332.432931 |
|
| 9 | -2039.715386 |
|
-315.338333 |
|
| 10 | -1713.391695 |
|
-260.319209 |
|
| 11 | -1622.059136 |
|
-137.869463 |
|
| 12 | -1485.477183 |
|
-135.476864 |
|
| 13 | -1428.848188 |
|
-67.700947 |
|
| 14 | -936.927971 |
|
-52.856141 |
|
| 15 | -902.302967 |
|
||
| 16 | -789.816863 |
|
||
| 17 | -485.046701 |
|
||
| 18 | -86.096691 |
|
||
| 19 | -57.339414 |
|
||
| 20 | -48.954794 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -20575.833835 |
|
-22736.221712 |
|
| 2 | -3237.255538 |
|
-4023.67547 |
|
| 3 | -2906.774252 |
|
-2967.389489 |
|
| 4 | -2543.036951 |
|
-2716.250024 |
|
| 5 | -2335.879657 |
|
-1598.11829 |
|
| 6 | -1994.326347 |
|
-942.262931 |
|
| 7 | -1770.678791 |
|
-227.93911 |
|
| 8 | -1543.947058 |
|
-169.663683 |
|
| 9 | -1412.25393 |
|
-111.560757 |
|
| 10 | -825.00352 |
|
-98.931624 |
|
| 11 | -711.648074 |
|
-79.098645 |
|
| 12 | -544.723705 |
|
-43.040025 |
|
| 13 | -529.923597 |
|
-30.807531 |
|
| 14 | -526.569705 |
|
-11.134274 |
|
| 15 | -431.276093 |
|
||
| 16 | -333.240831 |
|
||
| 17 | -304.799059 |
|
||
| 18 | -283.322544 |
|
||
| 19 | -171.00832 |
|
||
| 20 | -126.070474 |
|
||
| 21 | -21.889836 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 1.6e-100 |
|
| 3 | 4.1e-77 |
|
| 4 | 8.4e-59 |
|
| 5 | 2.8e-48 |
|
| 6 | 3.7e-25 |
|
| 7 | 7.1e-19 |
|
| 8 | 4.2e-14 |
|
| 9 | 2.2e-09 |
|
| 10 | 1.3e-08 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.7e-128 |
|
1.1e-75 |
|
| 3 | 1.1e-124 |
|
7.2e-50 |
|
| 4 | 9.3e-74 |
|
6.3e-41 |
|
| 5 | 3.3e-70 |
|
1.4e-36 |
|
| 6 | 4.8e-59 |
|
8.2e-31 |
|
| 7 | 6e-40 |
|
6.2e-07 |
|
| 8 | 6.6e-38 |
|
440.0 |
|
| 9 | 3.2e-27 |
|
8300.0 |
|
| 10 | 2e-21 |
|
150000.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 5e-58 |
|
2e-76 |
|
| 3 | 9.5e-47 |
|
9.5e-70 |
|
| 4 | 3.2e-44 |
|
2e-62 |
|
| 5 | 1.1e-45 |
|
3.6e-45 |
|
| 6 | 6.6e-27 |
|
6.7e-07 |
|
| 7 | 7.2e-23 |
|
12.0 |
|
| 8 | 2.7e-19 |
|
50000.0 |
|
| 9 | 1.4e-06 |
|
51000.0 |
|
| 10 | 0.13 |
|
73000.0 |
|