DiChIPMunk : on peaks and on multi-task seqlets and on single-task seqlets
HOMER : on peaks and on multi-task seqlets and on single-task seqlets
MEME : on peaks and on multitask seqlets and on single-task seqlets
Figure A: We show the motifs discovered by DiChIPMunk, HOMER, and MEME. We run these methods on the peaks, or on seqlets (i.e. high-importance windows of sequence identified by the neural network). Note that running these methods on seqlets generally gives a large advantage, which TF-MoDISco seeks to leverage further.
| Motif | Supporting sequences | PWM |
|---|---|---|
| 1 | 1800 |
|
| 2 | 2000 |
|
| 3 | 2000 |
|
| 4 | 2000 |
|
| 5 | 1628 |
|
| 6 | 913 |
|
| 7 | 335 |
|
| 8 | 86 |
|
| 9 | 25 |
|
| 10 | 18 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 13810 |
|
15317 |
|
| 2 | 2079 |
|
1322 |
|
| 3 | 659 |
|
175 |
|
| 4 | 413 |
|
120 |
|
| 5 | 78 |
|
||
| 6 | 44 |
|
| Motif | Supporting sequences (profile) | PWM (profile) | Supporting sequences (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 14846 |
|
16036 |
|
| 2 | 2017 |
|
1462 |
|
| 3 | 194 |
|
116 |
|
| 4 | 60 |
|
7 |
|
| 5 | 1 |
|
| Motif | Log enrichment | PWM |
|---|---|---|
| 1 | -23381.782555 |
|
| 2 | -6440.771162 |
|
| 3 | -3708.969408 |
|
| 4 | -3588.026123 |
|
| 5 | -3510.919406 |
|
| 6 | -3429.225319 |
|
| 7 | -3416.102803 |
|
| 8 | -2948.841 |
|
| 9 | -2829.056889 |
|
| 10 | -2386.236895 |
|
| 11 | -2265.972397 |
|
| 12 | -1428.377979 |
|
| 13 | -1363.737305 |
|
| 14 | -1306.367475 |
|
| 15 | -1077.45807 |
|
| 16 | -1065.271271 |
|
| 17 | -1032.047176 |
|
| 18 | -263.213401 |
|
| 19 | -250.175692 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -19855.090039 |
|
-30308.553771 |
|
| 2 | -3844.158413 |
|
-3770.46649 |
|
| 3 | -3248.946282 |
|
-3463.110153 |
|
| 4 | -2513.719948 |
|
-3146.785216 |
|
| 5 | -2286.655204 |
|
-2057.0444 |
|
| 6 | -2078.766947 |
|
-1943.708211 |
|
| 7 | -1430.88208 |
|
-1937.171771 |
|
| 8 | -1195.335244 |
|
-1117.527814 |
|
| 9 | -923.838882 |
|
-954.364358 |
|
| 10 | -744.774094 |
|
-688.308241 |
|
| 11 | -705.82604 |
|
-630.544162 |
|
| 12 | -694.621665 |
|
-274.660338 |
|
| 13 | -663.488113 |
|
-253.668958 |
|
| 14 | -601.862331 |
|
-218.411604 |
|
| 15 | -499.378094 |
|
||
| 16 | -440.609689 |
|
||
| 17 | -422.461764 |
|
||
| 18 | -347.915285 |
|
||
| 19 | -190.115833 |
|
||
| 20 | -103.957809 |
|
||
| 21 | -87.414862 |
|
| Motif | Log enrichment (profile) | PWM (profile) | Log enrichment (count) | PWM (count) |
|---|---|---|---|---|
| 1 | -29538.28702 |
|
-34742.471769 |
|
| 2 | -3550.748299 |
|
-3575.800943 |
|
| 3 | -2307.374426 |
|
-3525.369837 |
|
| 4 | -2126.663084 |
|
-2724.118078 |
|
| 5 | -1971.73812 |
|
-2575.222865 |
|
| 6 | -1634.300594 |
|
-2315.901311 |
|
| 7 | -1417.379139 |
|
-382.733068 |
|
| 8 | -618.322023 |
|
-232.623177 |
|
| 9 | -606.766173 |
|
-159.816938 |
|
| 10 | -445.740357 |
|
-150.988834 |
|
| 11 | -215.41867 |
|
-108.951224 |
|
| 12 | -189.390414 |
|
-90.560808 |
|
| 13 | -179.130107 |
|
-67.541734 |
|
| 14 | -169.360276 |
|
-52.08057 |
|
| 15 | -73.623228 |
|
-38.054462 |
|
| 16 | -19.95657 |
|
| Motif | E-value | PWM |
|---|---|---|
| 1 | 0.0 |
|
| 2 | 5.5e-294 |
|
| 3 | 2.7e-222 |
|
| 4 | 5.7e-75 |
|
| 5 | 5e-53 |
|
| 6 | 2.9e-39 |
|
| 7 | 4.2e-24 |
|
| 8 | 1.8e-21 |
|
| 9 | 2.3e-12 |
|
| 10 | 1.2e-11 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 2.3e-93 |
|
8.2e-107 |
|
| 3 | 4.2e-42 |
|
7.6e-34 |
|
| 4 | 2.2e-27 |
|
1.9e-13 |
|
| 5 | 5.9e-26 |
|
4.1e-11 |
|
| 6 | 5.7e-16 |
|
1.5 |
|
| 7 | 5.8e-08 |
|
0.028 |
|
| 8 | 4.7e-05 |
|
250.0 |
|
| 9 | 0.0013 |
|
730.0 |
|
| 10 | 0.011 |
|
78.0 |
|
| Motif | E-value (profile) | PWM (profile) | E-value (count) | PWM (count) |
|---|---|---|---|---|
| 1 | 0.0 |
|
0.0 |
|
| 2 | 1.2e-83 |
|
4.6e-68 |
|
| 3 | 1.6e-20 |
|
1.2e-34 |
|
| 4 | 2.7e-19 |
|
7.6e-27 |
|
| 5 | 5.8e-08 |
|
1.3e-20 |
|
| 6 | 0.28 |
|
1.9e-06 |
|
| 7 | 110.0 |
|
13.0 |
|
| 8 | 2200.0 |
|
43.0 |
|
| 9 | 2900.0 |
|
210.0 |
|
| 10 | 32000.0 |
|
270.0 |
|