In [1]:
# Parameters
data_name = "BRN;SNSR_MTR_CRTX;A;CL"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"
tomtom_report_root = "http://mitra.stanford.edu/kundaje/msharmin/report/tomtom_outs/cells"
task_dir = "task_71-naivegw"
perf_file = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/fineFactorized/task_71-naivegw/NaiveauPRC.txt"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
reportfile = "/mnt/lab_data/kundaje/msharmin/annotations/filtering samples_MS2.xlsx"
sheetname = "filter23"
In [2]:
from matlas.reports import display_metadata
load data from labcluster
Using TensorFlow backend.
2019-08-30 18:56:25,668 [WARNING] git-lfs not installed
In [3]:
display_metadata(data_name, perf_file, reportfile, sheetname)
    Sample Information
    MetaData NameDescription
    Cell typeBrain- Sensorimotor Cortex
    Cell GroupNeural Cells and Tissues
    Experiment NameATAC
    Experiment GroupCasellas Lab
    Pipeline Output
    replicateNaïve overlap peaksIDR peaksTSS enrichment (< 8 is very poor <10 is low)Final number of unique mapping, dup-filtered, chrM filtered readsNumber of reads in called peak regionsFraction of reads in called peak regionsNumber of reads in promoter regionsFraction of reads in promoter regionsNumber of reads in enhancer regionsFraction of reads in enhancer regions
    rep11535008613710.24055025835272406440.144147441620.0944199491230.3971
    Modelling Metadata
    MetricValue
    auPRC0.5747
    Calibrated Recall at 50% FDR0.258
    Number of Positive Examples in Test Data106022
    Number of Negative Examples in Test Data7964829
    Imbalance Ratio in Test Data0.0131
    Test Chromosomeschr2, chr3, chr19
In [4]:
from matlas.reports import display_paiwise_pattern_comparison
from matlas.reports import display_denovo_patterns
In [5]:
display_denovo_patterns(data_name, modisco_root=modisco_root)
TF-MoDISco is using the TensorFlow backend.
The following two links show list of Denovo Patterns and corresponding Motifs discovered by TF-MoDISco
Click here for Denovo Patterns by TF-MoDISco: #19
Pattern NameTF Name(s)Modisco
metacluster_1/pattern_0 # seqlets: 3573 SequenceContrib ScoresHyp_Contrib Scores
Egr2, Egr3, Zbtb17, Zfp281, Egr1, Gli3
metacluster_1/pattern_1 # seqlets: 2922 SequenceContrib ScoresHyp_Contrib Scores
Sp4, Sp3, Sp2, Sp1, Klf3, E2f4, Klf7, Klf8, Klf12, Klf6,

E2f1, Klf1, Klf4, Sp5, Klf5, Klf15, Wt1, Maz, Zfp740, E2f7, Zbtb1
metacluster_1/pattern_2 # seqlets: 2851 SequenceContrib ScoresHyp_Contrib Scores
Mef2a, Mef2c, Mef2d
metacluster_1/pattern_3 # seqlets: 2299 SequenceContrib ScoresHyp_Contrib Scores
Fosl2, Batf, Fos, Jdp2, Jund, Fosb, Junb, Fosl1, Atf3, Jun,

Bach2, Nfe2, Nfe2l2, Bach1, Mafa, Mafk
metacluster_1/pattern_4 # seqlets: 1770 SequenceContrib ScoresHyp_Contrib Scores
Ctcf, Ctcfl
metacluster_1/pattern_5 # seqlets: 1658 SequenceContrib ScoresHyp_Contrib Scores
Rfx2, Rfx3, Rfx1, Rfx4, Rfx6, Rfx7
metacluster_1/pattern_6 # seqlets: 1585 SequenceContrib ScoresHyp_Contrib Scores
Neurod2, Neurod1, Neurog2, Atoh1, Olig2, Tcf21, Bhlhe22, Lyl1, Msc, Neurog1,

Bhlha15, Msgn1, Tal1, Twist1, Ascl1, Tcf12, Twist2, Ptf1a, Myog, Ascl2, Snai1,

Tfap4
metacluster_1/pattern_7 # seqlets: 1509 SequenceContrib ScoresHyp_Contrib Scores
Nrf1, Zfx
metacluster_1/pattern_8 # seqlets: 1355 SequenceContrib ScoresHyp_Contrib Scores
Nfyb, Nfyc, Nfya, Foxi1, Pbx3
metacluster_1/pattern_9 # seqlets: 1263 SequenceContrib ScoresHyp_Contrib Scores
Nfib, Nfic, Nfia
metacluster_1/pattern_10 # seqlets: 1126 SequenceContrib ScoresHyp_Contrib Scores
Atf7, Atf2, Creb1, Creb5, Atf1, Crem, Nfil3, Mafb, Tef, Dbp,

Rxrb, Cebpb, Gmeb2
metacluster_1/pattern_11 # seqlets: 929 SequenceContrib ScoresHyp_Contrib Scores
Gabpa, Fli1, Ets1, Elk4, Elk1, Elf1, Erg, Elk3, Etv4, Etv2,

Etv1, Etv5, Fev, Etv3, XP_911724.4, Etv6, Ehf, Elf3, Elf4, Elf5, Spi1,

Elf2, Spdef, Irf8, Spib
metacluster_1/pattern_12 # seqlets: 552 SequenceContrib ScoresHyp_Contrib Scores
Thap11, Zfp143, Tbx2
metacluster_1/pattern_13 # seqlets: 531 SequenceContrib ScoresHyp_Contrib Scores
Hlf
metacluster_1/pattern_14 # seqlets: 500 SequenceContrib ScoresHyp_Contrib Scores
Yy1, Taf1, Zfp42
metacluster_1/pattern_15 # seqlets: 473 SequenceContrib ScoresHyp_Contrib Scores
Usf1, Usf2, Tfeb, Tfe3, Tfec, Arntl, Mitf, Bhlhe40, Srebf1, Arnt,

Mlx, Clock, Srebf2, Npas2, Tcfl5, Mycn, Bhlhe41, Max, Creb3l2, Myc
metacluster_1/pattern_16 # seqlets: 471 SequenceContrib ScoresHyp_Contrib Scores
Pou2f2, Pou2f1, Pou5f1
metacluster_1/pattern_17 # seqlets: 178 SequenceContrib ScoresHyp_Contrib Scores
Sox9, Sox2, Sox3, Sox10, Sox6, Sox4, Sox17
metacluster_1/pattern_18 # seqlets: 57 SequenceContrib ScoresHyp_Contrib Scores
Zbtb33
Click here for Motifs by TF-MoDISco: #162
TF NamePattern(s)
Egr2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00607113
metacluster_1/pattern_10.0264221
Egr3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00578408
metacluster_1/pattern_10.0366827
Zbtb17
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0163591
metacluster_1/pattern_10.000573245
metacluster_1/pattern_140.0252705
Zfp281
Pattern NameModiscoSignificance
metacluster_1/pattern_00.042569699999999995
metacluster_1/pattern_10.013315700000000001
Egr1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.017758700000000002
metacluster_1/pattern_10.020085
Gli3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.056634199999999996
Sp4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0012255999999999999
Sp3
Pattern NameModiscoSignificance
metacluster_1/pattern_13.9148400000000005e-06
metacluster_1/pattern_70.059455600000000004
metacluster_1/pattern_140.00018213900000000003
metacluster_1/pattern_180.00413265
Sp2
Pattern NameModiscoSignificance
metacluster_1/pattern_15.86587e-06
metacluster_1/pattern_70.0206483
metacluster_1/pattern_140.00011787399999999999
metacluster_1/pattern_180.00345313
Sp1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000407023
metacluster_1/pattern_140.00018213900000000003
metacluster_1/pattern_180.040301
Klf3
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000284442
metacluster_1/pattern_140.0252705
E2f4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00037117
Klf7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000514527
Klf8
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00103564
Klf12
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00109603
Klf6
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0012255999999999999
E2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00128611
Klf1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00800369
Klf4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00868001
Sp5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.009537200000000001
Klf5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0118728
Klf15
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0130477
Wt1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0147714
metacluster_1/pattern_140.049602099999999996
Maz
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0170312
metacluster_1/pattern_140.041634
Zfp740
Pattern NameModiscoSignificance
metacluster_1/pattern_10.028482599999999997
E2f7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0370956
Zbtb1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0507686
Mef2a
Pattern NameModiscoSignificance
metacluster_1/pattern_26.071810000000001e-06
Mef2c
Pattern NameModiscoSignificance
metacluster_1/pattern_25.45073e-10
Mef2d
Pattern NameModiscoSignificance
metacluster_1/pattern_27.102460000000001e-09
Fosl2
Pattern NameModiscoSignificance
metacluster_1/pattern_34.1545e-05
metacluster_1/pattern_100.052576099999999994
Batf
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00972455
Fos
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
Jdp2
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
metacluster_1/pattern_100.000584157
metacluster_1/pattern_150.0471365
Jund
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0034794000000000005
metacluster_1/pattern_100.054898300000000004
Fosb
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
Junb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0233878
Fosl1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0407778
metacluster_1/pattern_100.026808999999999996
Atf3
Pattern NameModiscoSignificance
metacluster_1/pattern_33.11769e-05
metacluster_1/pattern_100.0480301
Jun
Pattern NameModiscoSignificance
metacluster_1/pattern_30.031415
metacluster_1/pattern_100.0254198
Bach2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00417972
Nfe2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.007906100000000001
Nfe2l2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00898853
Bach1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00886297
Mafa
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0318532
Mafk
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0415211
Ctcf
Pattern NameModiscoSignificance
metacluster_1/pattern_43.75152e-14
Ctcfl
Pattern NameModiscoSignificance
metacluster_1/pattern_42.40238e-08
Rfx2
Pattern NameModiscoSignificance
metacluster_1/pattern_54.30352e-06
Rfx3
Pattern NameModiscoSignificance
metacluster_1/pattern_50.0044522
Rfx1
Pattern NameModiscoSignificance
metacluster_1/pattern_52.58548e-06
metacluster_1/pattern_140.0252705
Rfx4
Pattern NameModiscoSignificance
metacluster_1/pattern_54.93988e-05
Rfx6
Pattern NameModiscoSignificance
metacluster_1/pattern_50.000155011
Rfx7
Pattern NameModiscoSignificance
metacluster_1/pattern_50.00250549
Neurod2
Pattern NameModiscoSignificance
metacluster_1/pattern_62.68822e-06
Neurod1
Pattern NameModiscoSignificance
metacluster_1/pattern_63.8413e-05
Neurog2
Pattern NameModiscoSignificance
metacluster_1/pattern_61.59151e-05
Atoh1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00922273
Olig2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00058205
Tcf21
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Bhlhe22
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Lyl1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Msc
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00474727
Neurog1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00485971
Bhlha15
Pattern NameModiscoSignificance
metacluster_1/pattern_60.012074
Msgn1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.012525
Tal1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0199766
Twist1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021000799999999997
Ascl1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021315200000000003
Tcf12
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0586231
Twist2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021364599999999997
Ptf1a
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0229963
Myog
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0356887
Ascl2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0586231
Snai1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0463288
Tfap4
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0463288
Nrf1
Pattern NameModiscoSignificance
metacluster_1/pattern_71.2560700000000002e-06
Zfx
Pattern NameModiscoSignificance
metacluster_1/pattern_70.0186566
metacluster_1/pattern_140.004005699999999999
metacluster_1/pattern_180.00345313
Nfyb
Pattern NameModiscoSignificance
metacluster_1/pattern_81.7568799999999999e-12
Nfyc
Pattern NameModiscoSignificance
metacluster_1/pattern_82.5888e-10
Nfya
Pattern NameModiscoSignificance
metacluster_1/pattern_82.9701999999999997e-10
Foxi1
Pattern NameModiscoSignificance
metacluster_1/pattern_85.194500000000001e-06
Pbx3
Pattern NameModiscoSignificance
metacluster_1/pattern_81.0669200000000001e-05
Nfib
Pattern NameModiscoSignificance
metacluster_1/pattern_95.29643e-08
Nfic
Pattern NameModiscoSignificance
metacluster_1/pattern_90.00554647
Nfia
Pattern NameModiscoSignificance
metacluster_1/pattern_90.00621443
Atf7
Pattern NameModiscoSignificance
metacluster_1/pattern_104.95322e-05
metacluster_1/pattern_150.0355775
Atf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000219348
metacluster_1/pattern_150.0505158
Creb1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000492288
metacluster_1/pattern_150.031352
Creb5
Pattern NameModiscoSignificance
metacluster_1/pattern_102.28292e-05
metacluster_1/pattern_150.040075
Atf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.048568400000000005
metacluster_1/pattern_150.028819599999999997
Crem
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000958338
Nfil3
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00755819
metacluster_1/pattern_130.00657964
Mafb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00756691
Tef
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0161334
Dbp
Pattern NameModiscoSignificance
metacluster_1/pattern_100.050414099999999996
metacluster_1/pattern_130.05411749999999999
Rxrb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0340029
Cebpb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.055836000000000004
Gmeb2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0573193
Gabpa
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0007562830000000001
Fli1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0003202
Ets1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0003202
Elk4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000156315
Elk1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00011151600000000001
Elf1
Pattern NameModiscoSignificance
metacluster_1/pattern_113.16261e-06
Erg
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00031229099999999997
Elk3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00031229099999999997
Etv4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00735938
Etv2
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00015560000000000001
Etv1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000156315
Etv5
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000369122
Fev
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000594034
Etv3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000947613
XP_911724.4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00101502
Etv6
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0303735
Ehf
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00516118
Elf3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.025704599999999998
Elf4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00642772
Elf5
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0413596
Spi1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0249325
Elf2
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0251456
Spdef
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0217574
Irf8
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0413596
Spib
Pattern NameModiscoSignificance
metacluster_1/pattern_110.04179190000000001
Thap11
Pattern NameModiscoSignificance
metacluster_1/pattern_121.0722999999999998e-23
Zfp143
Pattern NameModiscoSignificance
metacluster_1/pattern_127.56432e-22
Tbx2
Pattern NameModiscoSignificance
metacluster_1/pattern_125.98955e-13
Hlf
Pattern NameModiscoSignificance
metacluster_1/pattern_130.0480515
metacluster_1/pattern_150.0246239
Yy1
Pattern NameModiscoSignificance
metacluster_1/pattern_142.93929e-06
Taf1
Pattern NameModiscoSignificance
metacluster_1/pattern_142.93929e-06
Zfp42
Pattern NameModiscoSignificance
metacluster_1/pattern_140.00649788
Usf1
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0189472
Usf2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.012203100000000001
Tfeb
Pattern NameModiscoSignificance
metacluster_1/pattern_150.000378235
Tfe3
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00172854
Tfec
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00181491
Arntl
Pattern NameModiscoSignificance
metacluster_1/pattern_150.016874
Mitf
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00089033
Bhlhe40
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00934069
Srebf1
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0304753
Arnt
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0471365
Mlx
Pattern NameModiscoSignificance
metacluster_1/pattern_150.010500399999999998
Clock
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0345854
Srebf2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00405432
Npas2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00416094
Tcfl5
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00807411
Mycn
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0197358
Bhlhe41
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0199645
Max
Pattern NameModiscoSignificance
metacluster_1/pattern_150.026109800000000002
Creb3l2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.039513099999999995
Myc
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0341483
Pou2f2
Pattern NameModiscoSignificance
metacluster_1/pattern_160.000773149
Pou2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_160.0127915
Pou5f1
Pattern NameModiscoSignificance
metacluster_1/pattern_160.0189035
Sox9
Pattern NameModiscoSignificance
metacluster_1/pattern_171.7764e-10
Sox2
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00043694400000000004
Sox3
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00795982
Sox10
Pattern NameModiscoSignificance
metacluster_1/pattern_170.0005942
Sox6
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00418211
Sox4
Pattern NameModiscoSignificance
metacluster_1/pattern_170.0168666
Sox17
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00795982
Zbtb33
Pattern NameModiscoSignificance
metacluster_1/pattern_183.97851e-06
In [6]:
display_paiwise_pattern_comparison(data_name, modisco_root, homer_root)
Number of CISBP TFs obtained by TF-MoDISco and Homer
Shared TFs between TF-MoDISco and Homer: #105
TF NameModiscoHomer
Elf2
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0251456
Pattern NameHomerSignificance
motif9.motif0.0207486
Zfx
Pattern NameModiscoSignificance
metacluster_1/pattern_70.0186566
metacluster_1/pattern_140.004005699999999999
metacluster_1/pattern_180.00345313
Pattern NameHomerSignificance
motif5.motif0.025872199999999998
Nfya
Pattern NameModiscoSignificance
metacluster_1/pattern_82.9701999999999997e-10
Pattern NameHomerSignificance
motif13.motif5.20009e-07
Atoh1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00922273
Pattern NameHomerSignificance
motif7.motif0.00170297
Klf1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00800369
Pattern NameHomerSignificance
motif5.motif0.0308007
Neurod2
Pattern NameModiscoSignificance
metacluster_1/pattern_62.68822e-06
Pattern NameHomerSignificance
motif7.motif9.18442e-07
Fev
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000594034
Pattern NameHomerSignificance
motif9.motif0.0163991
Fosl2
Pattern NameModiscoSignificance
metacluster_1/pattern_34.1545e-05
metacluster_1/pattern_100.052576099999999994
Pattern NameHomerSignificance
motif1.motif0.000179034
Zbtb33
Pattern NameModiscoSignificance
metacluster_1/pattern_183.97851e-06
Pattern NameHomerSignificance
motif19.motif0.000137179
Myc
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0341483
Pattern NameHomerSignificance
motif26.motif0.0322184
Elf1
Pattern NameModiscoSignificance
metacluster_1/pattern_113.16261e-06
Pattern NameHomerSignificance
motif9.motif0.00560466
Mef2a
Pattern NameModiscoSignificance
metacluster_1/pattern_26.071810000000001e-06
Pattern NameHomerSignificance
motif3.motif1.50298e-08
Msc
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00474727
Pattern NameHomerSignificance
motif7.motif0.00113431
Nfe2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.007906100000000001
Pattern NameHomerSignificance
motif1.motif0.00162291
Neurod1
Pattern NameModiscoSignificance
metacluster_1/pattern_63.8413e-05
Pattern NameHomerSignificance
motif7.motif1.0123200000000002e-06
XP_911724.4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00101502
Pattern NameHomerSignificance
motif9.motif0.034897000000000004
Junb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0233878
Pattern NameHomerSignificance
motif1.motif0.012726399999999999
Bach2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00417972
Pattern NameHomerSignificance
motif1.motif0.000990652
Ets1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0003202
Pattern NameHomerSignificance
motif9.motif0.034010000000000006
Gabpa
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0007562830000000001
Pattern NameHomerSignificance
motif9.motif0.0182056
Nfe2l2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00898853
Pattern NameHomerSignificance
motif1.motif0.00199979
Etv1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000156315
Pattern NameHomerSignificance
motif9.motif0.0207486
Fos
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
Pattern NameHomerSignificance
motif1.motif0.000179034
Ptf1a
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0229963
Pattern NameHomerSignificance
motif7.motif0.05719640000000001
Ctcfl
Pattern NameModiscoSignificance
metacluster_1/pattern_42.40238e-08
Pattern NameHomerSignificance
motif4.motif4.25566e-05
Olig2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00058205
Pattern NameHomerSignificance
motif7.motif0.00339195
Sp4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0012255999999999999
Pattern NameHomerSignificance
motif5.motif0.0326884
Zfp281
Pattern NameModiscoSignificance
metacluster_1/pattern_00.042569699999999995
metacluster_1/pattern_10.013315700000000001
Pattern NameHomerSignificance
motif2.motif0.0509057
Ascl2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0586231
Pattern NameHomerSignificance
motif7.motif0.024844
Zfp143
Pattern NameModiscoSignificance
metacluster_1/pattern_127.56432e-22
Pattern NameHomerSignificance
motif6.motif1.30987e-08
Ehf
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00516118
Pattern NameHomerSignificance
motif9.motif0.034010000000000006
Erg
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00031229099999999997
Pattern NameHomerSignificance
motif9.motif0.0315581
Fosb
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
Pattern NameHomerSignificance
motif1.motif0.000415337
Klf7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000514527
Pattern NameHomerSignificance
motif5.motif0.000914243
Tal1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0199766
Pattern NameHomerSignificance
motif7.motif0.049458499999999996
Lyl1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Pattern NameHomerSignificance
motif7.motif0.00437965
E2f4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00037117
Pattern NameHomerSignificance
motif5.motif0.000914243
Mafa
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0318532
Pattern NameHomerSignificance
motif1.motif0.0297289
Nfyc
Pattern NameModiscoSignificance
metacluster_1/pattern_82.5888e-10
Pattern NameHomerSignificance
motif13.motif5.20009e-07
Atf3
Pattern NameModiscoSignificance
metacluster_1/pattern_33.11769e-05
metacluster_1/pattern_100.0480301
Pattern NameHomerSignificance
motif1.motif0.000757924
Creb5
Pattern NameModiscoSignificance
metacluster_1/pattern_102.28292e-05
metacluster_1/pattern_150.040075
Pattern NameHomerSignificance
motif14.motif0.0112004
Creb1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000492288
metacluster_1/pattern_150.031352
Pattern NameHomerSignificance
motif14.motif0.0194668
Nrf1
Pattern NameModiscoSignificance
metacluster_1/pattern_71.2560700000000002e-06
Pattern NameHomerSignificance
motif8.motif2.7684400000000002e-05
Atf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.048568400000000005
metacluster_1/pattern_150.028819599999999997
Pattern NameHomerSignificance
motif14.motif0.0375173
Egr2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00607113
metacluster_1/pattern_10.0264221
Pattern NameHomerSignificance
motif2.motif0.039753699999999996
Bhlhe22
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Pattern NameHomerSignificance
motif7.motif0.000367087
Klf3
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000284442
metacluster_1/pattern_140.0252705
Pattern NameHomerSignificance
motif5.motif0.000961128
Rfx4
Pattern NameModiscoSignificance
metacluster_1/pattern_54.93988e-05
Pattern NameHomerSignificance
motif10.motif0.000332614
Etv3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000947613
Pattern NameHomerSignificance
motif9.motif0.037852699999999996
Nfil3
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00755819
metacluster_1/pattern_130.00657964
Pattern NameHomerSignificance
motif21.motif0.00311636
Dbp
Pattern NameModiscoSignificance
metacluster_1/pattern_100.050414099999999996
metacluster_1/pattern_130.05411749999999999
Pattern NameHomerSignificance
motif21.motif0.0457065
Atf7
Pattern NameModiscoSignificance
metacluster_1/pattern_104.95322e-05
metacluster_1/pattern_150.0355775
Pattern NameHomerSignificance
motif14.motif0.0211037
Neurog2
Pattern NameModiscoSignificance
metacluster_1/pattern_61.59151e-05
Pattern NameHomerSignificance
motif7.motif0.000193322
Rfx1
Pattern NameModiscoSignificance
metacluster_1/pattern_52.58548e-06
metacluster_1/pattern_140.0252705
Pattern NameHomerSignificance
motif10.motif0.000126099
Tcf21
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00365897
Pattern NameHomerSignificance
motif7.motif0.00378886
Mafk
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0415211
Pattern NameHomerSignificance
motif1.motif0.019532499999999998
Hlf
Pattern NameModiscoSignificance
metacluster_1/pattern_130.0480515
metacluster_1/pattern_150.0246239
Pattern NameHomerSignificance
motif21.motif0.0430361
Atf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000219348
metacluster_1/pattern_150.0505158
Pattern NameHomerSignificance
motif14.motif0.0223208
Elk1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00011151600000000001
Pattern NameHomerSignificance
motif9.motif0.018140700000000003
Nfyb
Pattern NameModiscoSignificance
metacluster_1/pattern_81.7568799999999999e-12
Pattern NameHomerSignificance
motif13.motif2.82331e-09
Etv5
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000369122
Pattern NameHomerSignificance
motif9.motif0.011054000000000001
Crem
Pattern NameModiscoSignificance
metacluster_1/pattern_100.000958338
Pattern NameHomerSignificance
motif14.motif0.014315999999999999
Sp1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.000407023
metacluster_1/pattern_140.00018213900000000003
metacluster_1/pattern_180.040301
Pattern NameHomerSignificance
motif5.motif0.00620875
Mafb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00756691
Pattern NameHomerSignificance
motif1.motif0.0439784
Klf6
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0012255999999999999
Pattern NameHomerSignificance
motif5.motif0.00620875
Rfx7
Pattern NameModiscoSignificance
metacluster_1/pattern_50.00250549
Pattern NameHomerSignificance
motif10.motif0.0197512
motif24.motif0.0159871
Rfx3
Pattern NameModiscoSignificance
metacluster_1/pattern_50.0044522
Pattern NameHomerSignificance
motif10.motif0.0465332
Klf8
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00103564
Pattern NameHomerSignificance
motif5.motif0.00161781
Foxi1
Pattern NameModiscoSignificance
metacluster_1/pattern_85.194500000000001e-06
Pattern NameHomerSignificance
motif13.motif7.412189999999999e-06
Msgn1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.012525
Pattern NameHomerSignificance
motif7.motif0.00113431
Sp3
Pattern NameModiscoSignificance
metacluster_1/pattern_13.9148400000000005e-06
metacluster_1/pattern_70.059455600000000004
metacluster_1/pattern_140.00018213900000000003
metacluster_1/pattern_180.00413265
Pattern NameHomerSignificance
motif5.motif0.000914243
Rfx6
Pattern NameModiscoSignificance
metacluster_1/pattern_50.000155011
Pattern NameHomerSignificance
motif10.motif0.0206421
Klf12
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00109603
Pattern NameHomerSignificance
motif5.motif0.0308007
E2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00128611
Pattern NameHomerSignificance
motif5.motif0.0401507
Ctcf
Pattern NameModiscoSignificance
metacluster_1/pattern_43.75152e-14
Pattern NameHomerSignificance
motif4.motif3.33921e-07
Fosl1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0407778
metacluster_1/pattern_100.026808999999999996
Pattern NameHomerSignificance
motif1.motif0.0269666
Bach1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00886297
Pattern NameHomerSignificance
motif1.motif0.00199979
Elk4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.000156315
Pattern NameHomerSignificance
motif9.motif0.0245183
Elf3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.025704599999999998
Pattern NameHomerSignificance
motif9.motif0.0585684
Klf5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0118728
Pattern NameHomerSignificance
motif5.motif0.0326884
Neurog1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00485971
Pattern NameHomerSignificance
motif7.motif0.0010107
Bhlha15
Pattern NameModiscoSignificance
metacluster_1/pattern_60.012074
Pattern NameHomerSignificance
motif7.motif0.0055931999999999996
Jund
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0034794000000000005
metacluster_1/pattern_100.054898300000000004
Pattern NameHomerSignificance
motif1.motif0.00283272
Egr1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.017758700000000002
metacluster_1/pattern_10.020085
Pattern NameHomerSignificance
motif2.motif0.05779259999999999
motif5.motif0.0367639
Zbtb1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0507686
Pattern NameHomerSignificance
motif5.motif0.039020400000000004
Egr3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00578408
metacluster_1/pattern_10.0366827
Pattern NameHomerSignificance
motif2.motif0.0383895
Mef2c
Pattern NameModiscoSignificance
metacluster_1/pattern_25.45073e-10
Pattern NameHomerSignificance
motif3.motif6.144840000000001e-10
Batf
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00972455
Pattern NameHomerSignificance
motif1.motif0.0436834
Klf4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00868001
Pattern NameHomerSignificance
motif2.motif0.039753699999999996
motif5.motif0.000914243
Elf4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00642772
Pattern NameHomerSignificance
motif9.motif0.023974099999999998
Elk3
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00031229099999999997
Pattern NameHomerSignificance
motif9.motif0.0182056
Etv4
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00735938
Pattern NameHomerSignificance
motif9.motif0.0207486
Tbx2
Pattern NameModiscoSignificance
metacluster_1/pattern_125.98955e-13
Pattern NameHomerSignificance
motif6.motif1.59113e-06
Sp2
Pattern NameModiscoSignificance
metacluster_1/pattern_15.86587e-06
metacluster_1/pattern_70.0206483
metacluster_1/pattern_140.00011787399999999999
metacluster_1/pattern_180.00345313
Pattern NameHomerSignificance
motif5.motif0.0008932139999999999
Rfx2
Pattern NameModiscoSignificance
metacluster_1/pattern_54.30352e-06
Pattern NameHomerSignificance
motif10.motif7.638689999999999e-05
Elf5
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0413596
Pattern NameHomerSignificance
motif9.motif0.0163991
Thap11
Pattern NameModiscoSignificance
metacluster_1/pattern_121.0722999999999998e-23
Pattern NameHomerSignificance
motif6.motif1.9114599999999998e-07
Pbx3
Pattern NameModiscoSignificance
metacluster_1/pattern_81.0669200000000001e-05
Pattern NameHomerSignificance
motif13.motif7.257989999999999e-05
Fli1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0003202
Pattern NameHomerSignificance
motif9.motif0.0308129
Twist2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021364599999999997
Pattern NameHomerSignificance
motif7.motif0.00378886
Jdp2
Pattern NameModiscoSignificance
metacluster_1/pattern_31.9706099999999998e-05
metacluster_1/pattern_100.000584157
metacluster_1/pattern_150.0471365
Pattern NameHomerSignificance
motif1.motif0.000179034
motif14.motif0.0405584
Gli3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.056634199999999996
Pattern NameHomerSignificance
motif2.motif0.0202743
Etv6
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0303735
Pattern NameHomerSignificance
motif9.motif0.0301062
Mef2d
Pattern NameModiscoSignificance
metacluster_1/pattern_27.102460000000001e-09
Pattern NameHomerSignificance
motif3.motif7.780160000000001e-10
Jun
Pattern NameModiscoSignificance
metacluster_1/pattern_30.031415
metacluster_1/pattern_100.0254198
Pattern NameHomerSignificance
motif1.motif0.025468400000000002
Unique TF-MoDISco TFs: #57
TF NameModiscoHomer
Zbtb17
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0163591
metacluster_1/pattern_10.000573245
metacluster_1/pattern_140.0252705
Absent
Taf1
Pattern NameModiscoSignificance
metacluster_1/pattern_142.93929e-06
Absent
Spi1
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0249325
Absent
Npas2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00416094
Absent
Sp5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.009537200000000001
Absent
Wt1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0147714
metacluster_1/pattern_140.049602099999999996
Absent
Sox17
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00795982
Absent
Zfp42
Pattern NameModiscoSignificance
metacluster_1/pattern_140.00649788
Absent
Bhlhe40
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00934069
Absent
Spib
Pattern NameModiscoSignificance
metacluster_1/pattern_110.04179190000000001
Absent
Mlx
Pattern NameModiscoSignificance
metacluster_1/pattern_150.010500399999999998
Absent
Nfia
Pattern NameModiscoSignificance
metacluster_1/pattern_90.00621443
Absent
Usf2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.012203100000000001
Absent
Max
Pattern NameModiscoSignificance
metacluster_1/pattern_150.026109800000000002
Absent
Rxrb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0340029
Absent
Pou2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_160.0127915
Absent
Sox3
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00795982
Absent
Etv2
Pattern NameModiscoSignificance
metacluster_1/pattern_110.00015560000000000001
Absent
Mitf
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00089033
Absent
Sox6
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00418211
Absent
Yy1
Pattern NameModiscoSignificance
metacluster_1/pattern_142.93929e-06
Absent
Pou2f2
Pattern NameModiscoSignificance
metacluster_1/pattern_160.000773149
Absent
Klf15
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0130477
Absent
Nfic
Pattern NameModiscoSignificance
metacluster_1/pattern_90.00554647
Absent
Mycn
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0197358
Absent
Clock
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0345854
Absent
Ascl1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021315200000000003
Absent
Arnt
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0471365
Absent
Tcf12
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0586231
Absent
Gmeb2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0573193
Absent
Tfap4
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0463288
Absent
Irf8
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0413596
Absent
Nfib
Pattern NameModiscoSignificance
metacluster_1/pattern_95.29643e-08
Absent
Creb3l2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.039513099999999995
Absent
Pou5f1
Pattern NameModiscoSignificance
metacluster_1/pattern_160.0189035
Absent
Zfp740
Pattern NameModiscoSignificance
metacluster_1/pattern_10.028482599999999997
Absent
Tef
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0161334
Absent
Tfeb
Pattern NameModiscoSignificance
metacluster_1/pattern_150.000378235
Absent
Bhlhe41
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0199645
Absent
Maz
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0170312
metacluster_1/pattern_140.041634
Absent
Tfec
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00181491
Absent
Snai1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0463288
Absent
Sox9
Pattern NameModiscoSignificance
metacluster_1/pattern_171.7764e-10
Absent
Twist1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.021000799999999997
Absent
Myog
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0356887
Absent
Spdef
Pattern NameModiscoSignificance
metacluster_1/pattern_110.0217574
Absent
Usf1
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0189472
Absent
Srebf1
Pattern NameModiscoSignificance
metacluster_1/pattern_150.0304753
Absent
Tcfl5
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00807411
Absent
Tfe3
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00172854
Absent
E2f7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0370956
Absent
Sox2
Pattern NameModiscoSignificance
metacluster_1/pattern_170.00043694400000000004
Absent
Cebpb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.055836000000000004
Absent
Srebf2
Pattern NameModiscoSignificance
metacluster_1/pattern_150.00405432
Absent
Arntl
Pattern NameModiscoSignificance
metacluster_1/pattern_150.016874
Absent
Sox10
Pattern NameModiscoSignificance
metacluster_1/pattern_170.0005942
Absent
Sox4
Pattern NameModiscoSignificance
metacluster_1/pattern_170.0168666
Absent
Unique Homer TFs: #5
TF NameModiscoHomer
MafAbsent
Pattern NameHomerSignificance
motif1.motif0.0505743
Gli2Absent
Pattern NameHomerSignificance
motif2.motif0.051904700000000005
Gli1Absent
Pattern NameHomerSignificance
motif2.motif0.053468100000000005
MafgAbsent
Pattern NameHomerSignificance
motif1.motif0.0439784
Sall4Absent
Pattern NameHomerSignificance
motif2.motif0.024488