In [1]:
# Parameters
data_name = "NTRPHL;A;CL"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"
tomtom_report_root = "http://mitra.stanford.edu/kundaje/msharmin/report/tomtom_outs/cells"
task_dir = "task_22-naivegw"
perf_file = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/fineFactorized/task_22-naivegw/NaiveauPRC.txt"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
reportfile = "/mnt/lab_data/kundaje/msharmin/annotations/filtering samples_MS2.xlsx"
sheetname = "filter23"
In [2]:
from matlas.reports import display_metadata
load data from labcluster
Using TensorFlow backend.
2019-08-30 18:45:12,346 [WARNING] git-lfs not installed
In [3]:
display_metadata(data_name, perf_file, reportfile, sheetname)
    Sample Information
    MetaData NameDescription
    Cell typeneutrophils
    Cell GroupOther Immune Cells
    Experiment NameATAC
    Experiment GroupCasellas Lab
    Pipeline Output
    replicateNaïve overlap peaksIDR peaksTSS enrichment (< 8 is very poor <10 is low)Final number of unique mapping, dup-filtered, chrM filtered readsNumber of reads in called peak regionsFraction of reads in called peak regionsNumber of reads in promoter regionsFraction of reads in promoter regionsNumber of reads in enhancer regionsFraction of reads in enhancer regions
    rep1652164578710.53295644675865005670.115258746980.1041179675660.3184
    Modelling Metadata
    MetricValue
    auPRC0.6356
    Calibrated Recall at 50% FDR0.202
    Number of Positive Examples in Test Data53794
    Number of Negative Examples in Test Data8017057
    Imbalance Ratio in Test Data0.0067
    Test Chromosomeschr2, chr3, chr19
In [4]:
from matlas.reports import display_paiwise_pattern_comparison
from matlas.reports import display_denovo_patterns
In [5]:
display_denovo_patterns(data_name, modisco_root=modisco_root)
TF-MoDISco is using the TensorFlow backend.
The following two links show list of Denovo Patterns and corresponding Motifs discovered by TF-MoDISco
Click here for Denovo Patterns by TF-MoDISco: #21
Pattern NameTF Name(s)Modisco
metacluster_1/pattern_0 # seqlets: 6619 SequenceContrib ScoresHyp_Contrib Scores
Spib, Spi1, Irf8, Irf4, Spic, Etv2, Ets1, Etv6, Erg, Ehf,

Etv4, Etv3, Elf3, Fli1, XP_911724.4, Elf4, Gabpa, Elk1, Elf1, Elf2, Elk4,

Elk3, Prdm1, Irf3, Irf2, Etv5, Etv1, Elf5, Irf1, Fev, Spdef
metacluster_1/pattern_1 # seqlets: 3788 SequenceContrib ScoresHyp_Contrib Scores
Sp4, Sp2, Klf3, Sp3, Sp1, Klf6, E2f4, Klf7, Klf4, Klf8,

Klf1, Klf12, Egr1, Egr2, Zbtb17, Sp5, E2f1, Klf5, Zfp281, Egr3, Zfx
metacluster_1/pattern_2 # seqlets: 1886 SequenceContrib ScoresHyp_Contrib Scores
Ctcf, Ctcfl
metacluster_1/pattern_3 # seqlets: 1529 SequenceContrib ScoresHyp_Contrib Scores
Creb1, Atf7, Atf2, Jdp2, Creb5, Atf3, Crem, Atf1, Mafb, Fosl2,

Fosl1, Jun, Nfil3, Tef, Hlf, Dbp, Cebpg, Tfe3, Jund, Gmeb2, Atf4,

Creb3l2, Cebpb, Junb, Rorb
metacluster_1/pattern_4 # seqlets: 1501 SequenceContrib ScoresHyp_Contrib Scores
Cebpa, Cebpd, Ddit3, Cebpe, Pou3f3
metacluster_1/pattern_5 # seqlets: 1483 SequenceContrib ScoresHyp_Contrib Scores
Nrf1
metacluster_1/pattern_6 # seqlets: 1388 SequenceContrib ScoresHyp_Contrib Scores
Bach2, Fosb, Nfe2l2, Bach1, Nfe2, Fos, Batf, Mafk, Mafa, Mafg,

Maf
metacluster_1/pattern_7 # seqlets: 1335 SequenceContrib ScoresHyp_Contrib Scores
Nfyb, Nfyc, Nfya, Foxi1, Pbx3
metacluster_1/pattern_8 # seqlets: 924 SequenceContrib ScoresHyp_Contrib Scores
Taf1, Yy1, Rfx1, Zfp42, Wt1, Maz
metacluster_1/pattern_9 # seqlets: 680 SequenceContrib ScoresHyp_Contrib Scores
Zfp143, Thap11, Tbx2
metacluster_1/pattern_10 # seqlets: 658 SequenceContrib ScoresHyp_Contrib Scores
Usf1, Tfec, Tfeb, Mitf, Arntl, Usf2, Srebf1, Bhlhe40, Mlx, Clock,

Arnt, Npas2, Srebf2, Tcfl5, Bhlhe41, Arnt2, Mlxip, Xbp1
metacluster_1/pattern_11 # seqlets: 560 SequenceContrib ScoresHyp_Contrib Scores
metacluster_1/pattern_12 # seqlets: 511 SequenceContrib ScoresHyp_Contrib Scores
Irf7, Stat1, Irf9, Stat2, Batf3
metacluster_1/pattern_13 # seqlets: 510 SequenceContrib ScoresHyp_Contrib Scores
metacluster_1/pattern_14 # seqlets: 229 SequenceContrib ScoresHyp_Contrib Scores
Rfx3, Rfx2, Rfx4, Rfx7, Rfx6
metacluster_1/pattern_15 # seqlets: 212 SequenceContrib ScoresHyp_Contrib Scores
metacluster_1/pattern_16 # seqlets: 204 SequenceContrib ScoresHyp_Contrib Scores
Nfkb1, Rela, Nfkb2, Relb, Rel
metacluster_1/pattern_17 # seqlets: 161 SequenceContrib ScoresHyp_Contrib Scores
Zbtb33
metacluster_1/pattern_18 # seqlets: 110 SequenceContrib ScoresHyp_Contrib Scores
Pou2f2
metacluster_1/pattern_19 # seqlets: 55 SequenceContrib ScoresHyp_Contrib Scores
metacluster_1/pattern_20 # seqlets: 30 SequenceContrib ScoresHyp_Contrib Scores
Nfia
Click here for Motifs by TF-MoDISco: #146
TF NamePattern(s)
Spib
Pattern NameModiscoSignificance
metacluster_1/pattern_02.8430400000000004e-06
metacluster_1/pattern_120.0009991289999999999
metacluster_1/pattern_130.033230199999999994
Spi1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000398862
metacluster_1/pattern_130.054105099999999996
Irf8
Pattern NameModiscoSignificance
metacluster_1/pattern_04.5818699999999996e-05
metacluster_1/pattern_123.75237e-06
metacluster_1/pattern_130.0340518
Irf4
Pattern NameModiscoSignificance
metacluster_1/pattern_05.64183e-05
metacluster_1/pattern_120.029095799999999998
metacluster_1/pattern_130.033230199999999994
Spic
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000398862
metacluster_1/pattern_130.0118288
Etv2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000525315
Ets1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Etv6
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0058728
Erg
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
metacluster_1/pattern_110.0420147
Ehf
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0099521
metacluster_1/pattern_110.0420147
Etv4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00799469
metacluster_1/pattern_110.0420147
Etv3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Elf3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.016066399999999998
Fli1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0117533
metacluster_1/pattern_110.0420147
XP_911724.4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Elf4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Gabpa
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0431798
metacluster_1/pattern_110.00248793
Elk1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0058728
metacluster_1/pattern_110.0263969
Elf1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Elf2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.035459899999999996
metacluster_1/pattern_110.0263969
Elk4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00587973
Elk3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.007441800000000001
Prdm1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0051467
metacluster_1/pattern_122.69482e-05
Irf3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00569724
metacluster_1/pattern_120.0006986939999999999
Irf2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.006852
metacluster_1/pattern_120.00125738
Etv5
Pattern NameModiscoSignificance
metacluster_1/pattern_00.007196800000000001
Etv1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00799469
Elf5
Pattern NameModiscoSignificance
metacluster_1/pattern_00.020663900000000002
Irf1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00862861
metacluster_1/pattern_125.957080000000001e-14
Fev
Pattern NameModiscoSignificance
metacluster_1/pattern_00.024105200000000004
Spdef
Pattern NameModiscoSignificance
metacluster_1/pattern_00.035459899999999996
Sp4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00233768
Sp2
Pattern NameModiscoSignificance
metacluster_1/pattern_18.60382e-06
metacluster_1/pattern_86.10787e-05
metacluster_1/pattern_170.000200947
Klf3
Pattern NameModiscoSignificance
metacluster_1/pattern_11.2780999999999998e-05
metacluster_1/pattern_80.039794699999999995
Sp3
Pattern NameModiscoSignificance
metacluster_1/pattern_11.54371e-05
metacluster_1/pattern_80.0007155169999999999
metacluster_1/pattern_170.00325765
Sp1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0009283469999999999
metacluster_1/pattern_80.000250049
metacluster_1/pattern_170.00235385
Klf6
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0005487469999999999
E2f4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0005487469999999999
Klf7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0008310310000000001
Klf4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.017782
Klf8
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00131391
Klf1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0587346
Klf12
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0185347
Egr1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0447087
Egr2
Pattern NameModiscoSignificance
metacluster_1/pattern_10.055281500000000004
metacluster_1/pattern_80.0500575
Zbtb17
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0101761
metacluster_1/pattern_80.016919299999999998
Sp5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0153213
E2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0200052
Klf5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.025896199999999998
Zfp281
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0347361
Egr3
Pattern NameModiscoSignificance
metacluster_1/pattern_10.058297400000000006
Zfx
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0587346
metacluster_1/pattern_80.00318115
metacluster_1/pattern_170.00309348
Ctcf
Pattern NameModiscoSignificance
metacluster_1/pattern_21.3779999999999998e-11
Ctcfl
Pattern NameModiscoSignificance
metacluster_1/pattern_28.61523e-10
Creb1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00038311800000000005
Atf7
Pattern NameModiscoSignificance
metacluster_1/pattern_35.2358199999999996e-05
Atf2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.000215897
Jdp2
Pattern NameModiscoSignificance
metacluster_1/pattern_35.2358199999999996e-05
metacluster_1/pattern_60.00212269
Creb5
Pattern NameModiscoSignificance
metacluster_1/pattern_34.66329e-05
Atf3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00430286
metacluster_1/pattern_63.1446300000000004e-05
Crem
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00173588
Atf1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.015092700000000002
metacluster_1/pattern_100.0145487
Mafb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00275545
metacluster_1/pattern_60.052031299999999996
Fosl2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00279567
metacluster_1/pattern_60.00109613
Fosl1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00316501
metacluster_1/pattern_63.1446300000000004e-05
Jun
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0201731
metacluster_1/pattern_63.1446300000000004e-05
Nfil3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00686804
metacluster_1/pattern_40.031927199999999996
Tef
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0106866
metacluster_1/pattern_40.013297
Hlf
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0257885
metacluster_1/pattern_40.031192900000000003
metacluster_1/pattern_100.0378369
Dbp
Pattern NameModiscoSignificance
metacluster_1/pattern_30.035988099999999995
metacluster_1/pattern_40.0236211
metacluster_1/pattern_100.038905800000000004
Cebpg
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0355206
metacluster_1/pattern_40.0047512
Tfe3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.035988099999999995
metacluster_1/pattern_100.00306446
Jund
Pattern NameModiscoSignificance
metacluster_1/pattern_30.042917500000000004
metacluster_1/pattern_60.0269403
Gmeb2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.042917500000000004
Atf4
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0525279
metacluster_1/pattern_40.00616959
Creb3l2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_100.054163499999999996
Cebpb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_40.00528144
Junb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_63.1446300000000004e-05
Rorb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
Cebpa
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00673096
Cebpd
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00528144
Ddit3
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00232538
Cebpe
Pattern NameModiscoSignificance
metacluster_1/pattern_40.0157049
Pou3f3
Pattern NameModiscoSignificance
metacluster_1/pattern_40.0576943
Nrf1
Pattern NameModiscoSignificance
metacluster_1/pattern_51.75347e-08
Bach2
Pattern NameModiscoSignificance
metacluster_1/pattern_63.1446300000000004e-05
Fosb
Pattern NameModiscoSignificance
metacluster_1/pattern_63.1446300000000004e-05
Nfe2l2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00020946799999999998
Bach1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.000125785
Nfe2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00020946799999999998
Fos
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00030885900000000003
Batf
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00385253
Mafk
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0274796
Mafa
Pattern NameModiscoSignificance
metacluster_1/pattern_60.040951
Mafg
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0423286
Maf
Pattern NameModiscoSignificance
metacluster_1/pattern_60.044366300000000004
Nfyb
Pattern NameModiscoSignificance
metacluster_1/pattern_71.1337100000000001e-13
Nfyc
Pattern NameModiscoSignificance
metacluster_1/pattern_72.43458e-11
Nfya
Pattern NameModiscoSignificance
metacluster_1/pattern_75.440269999999999e-10
Foxi1
Pattern NameModiscoSignificance
metacluster_1/pattern_75.12928e-06
Pbx3
Pattern NameModiscoSignificance
metacluster_1/pattern_75.22205e-06
Taf1
Pattern NameModiscoSignificance
metacluster_1/pattern_85.47234e-06
Yy1
Pattern NameModiscoSignificance
metacluster_1/pattern_81.4801199999999998e-05
Rfx1
Pattern NameModiscoSignificance
metacluster_1/pattern_80.017743599999999998
metacluster_1/pattern_141.10901e-09
Zfp42
Pattern NameModiscoSignificance
metacluster_1/pattern_80.0187042
Wt1
Pattern NameModiscoSignificance
metacluster_1/pattern_80.0310524
Maz
Pattern NameModiscoSignificance
metacluster_1/pattern_80.039794699999999995
Zfp143
Pattern NameModiscoSignificance
metacluster_1/pattern_94.603630000000001e-22
Thap11
Pattern NameModiscoSignificance
metacluster_1/pattern_97.165739999999999e-21
Tbx2
Pattern NameModiscoSignificance
metacluster_1/pattern_96.63534e-14
Usf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00409131
Tfec
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00265047
Tfeb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00117875
Mitf
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0021098000000000002
Arntl
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00548107
Usf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00330404
Srebf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00227077
Bhlhe40
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00548107
Mlx
Pattern NameModiscoSignificance
metacluster_1/pattern_100.026372700000000002
Clock
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0420894
Arnt
Pattern NameModiscoSignificance
metacluster_1/pattern_100.034058
Npas2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00315195
Srebf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00321226
Tcfl5
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00408832
Bhlhe41
Pattern NameModiscoSignificance
metacluster_1/pattern_100.013387
Arnt2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0420894
Mlxip
Pattern NameModiscoSignificance
metacluster_1/pattern_100.04810759999999999
Xbp1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.054163499999999996
Irf7
Pattern NameModiscoSignificance
metacluster_1/pattern_123.83379e-05
Stat1
Pattern NameModiscoSignificance
metacluster_1/pattern_126.993220000000001e-05
Irf9
Pattern NameModiscoSignificance
metacluster_1/pattern_120.0006986939999999999
Stat2
Pattern NameModiscoSignificance
metacluster_1/pattern_120.000772417
Batf3
Pattern NameModiscoSignificance
metacluster_1/pattern_120.00656011
Rfx3
Pattern NameModiscoSignificance
metacluster_1/pattern_140.000882345
Rfx2
Pattern NameModiscoSignificance
metacluster_1/pattern_140.0355302
Rfx4
Pattern NameModiscoSignificance
metacluster_1/pattern_146.07901e-05
Rfx7
Pattern NameModiscoSignificance
metacluster_1/pattern_140.000581583
Rfx6
Pattern NameModiscoSignificance
metacluster_1/pattern_140.00121012
Nfkb1
Pattern NameModiscoSignificance
metacluster_1/pattern_166.846559999999999e-07
Rela
Pattern NameModiscoSignificance
metacluster_1/pattern_163.91498e-05
Nfkb2
Pattern NameModiscoSignificance
metacluster_1/pattern_168.21883e-06
Relb
Pattern NameModiscoSignificance
metacluster_1/pattern_163.13794e-05
Rel
Pattern NameModiscoSignificance
metacluster_1/pattern_160.00550838
Zbtb33
Pattern NameModiscoSignificance
metacluster_1/pattern_175.13698e-05
Pou2f2
Pattern NameModiscoSignificance
metacluster_1/pattern_187.720390000000001e-05
Nfia
Pattern NameModiscoSignificance
metacluster_1/pattern_201.08845e-05
In [6]:
display_paiwise_pattern_comparison(data_name, modisco_root, homer_root)
Number of CISBP TFs obtained by TF-MoDISco and Homer
Shared TFs between TF-MoDISco and Homer: #98
TF NameModiscoHomer
Tfec
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00265047
Pattern NameHomerSignificance
motif6.motif0.022210499999999998
XP_911724.4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Pattern NameHomerSignificance
motif1.motif1.61806e-05
Foxi1
Pattern NameModiscoSignificance
metacluster_1/pattern_75.12928e-06
Pattern NameHomerSignificance
motif4.motif0.000465794
Fev
Pattern NameModiscoSignificance
metacluster_1/pattern_00.024105200000000004
Pattern NameHomerSignificance
motif1.motif0.011151399999999999
Tfeb
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00117875
Pattern NameHomerSignificance
motif6.motif0.0366099
Nfya
Pattern NameModiscoSignificance
metacluster_1/pattern_75.440269999999999e-10
Pattern NameHomerSignificance
motif4.motif6.44721e-07
Jund
Pattern NameModiscoSignificance
metacluster_1/pattern_30.042917500000000004
metacluster_1/pattern_60.0269403
Pattern NameHomerSignificance
motif3.motif0.03967
Dbp
Pattern NameModiscoSignificance
metacluster_1/pattern_30.035988099999999995
metacluster_1/pattern_40.0236211
metacluster_1/pattern_100.038905800000000004
Pattern NameHomerSignificance
motif3.motif0.052172699999999995
Sp1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0009283469999999999
metacluster_1/pattern_80.000250049
metacluster_1/pattern_170.00235385
Pattern NameHomerSignificance
motif2.motif0.0127835
Atf2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.000215897
Pattern NameHomerSignificance
motif3.motif0.0332029
motif6.motif0.0316632
Nfe2l2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00020946799999999998
Pattern NameHomerSignificance
motif3.motif0.0161442
Fosb
Pattern NameModiscoSignificance
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.052172699999999995
Zbtb33
Pattern NameModiscoSignificance
metacluster_1/pattern_175.13698e-05
Pattern NameHomerSignificance
motif12.motif9.93411e-09
Klf12
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0185347
Pattern NameHomerSignificance
motif2.motif0.00454206
Nfil3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00686804
metacluster_1/pattern_40.031927199999999996
Pattern NameHomerSignificance
motif3.motif0.0463801
Cebpd
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00528144
Pattern NameHomerSignificance
motif3.motif0.034499699999999994
Xbp1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.054163499999999996
Pattern NameHomerSignificance
motif6.motif0.050051599999999995
Spi1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000398862
metacluster_1/pattern_130.054105099999999996
Pattern NameHomerSignificance
motif1.motif0.0339324
Usf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00330404
Pattern NameHomerSignificance
motif6.motif0.022210499999999998
Elk3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.007441800000000001
Pattern NameHomerSignificance
motif1.motif0.000964065
Tfe3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.035988099999999995
metacluster_1/pattern_100.00306446
Pattern NameHomerSignificance
motif6.motif0.0268955
Hlf
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0257885
metacluster_1/pattern_40.031192900000000003
metacluster_1/pattern_100.0378369
Pattern NameHomerSignificance
motif3.motif0.05908290000000001
Elf2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.035459899999999996
metacluster_1/pattern_110.0263969
Pattern NameHomerSignificance
motif1.motif0.0058357
Elf4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Pattern NameHomerSignificance
motif1.motif0.000403325
Nfyb
Pattern NameModiscoSignificance
metacluster_1/pattern_71.1337100000000001e-13
Pattern NameHomerSignificance
motif4.motif2.75365e-08
Fli1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0117533
metacluster_1/pattern_110.0420147
Pattern NameHomerSignificance
motif1.motif0.00130764
Ctcfl
Pattern NameModiscoSignificance
metacluster_1/pattern_28.61523e-10
Pattern NameHomerSignificance
motif10.motif6.87607e-05
Ehf
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0099521
metacluster_1/pattern_110.0420147
Pattern NameHomerSignificance
motif1.motif0.0417444
Spic
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000398862
metacluster_1/pattern_130.0118288
Pattern NameHomerSignificance
motif1.motif0.000575074
Etv2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.000525315
Pattern NameHomerSignificance
motif1.motif0.00350377
Egr1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0447087
Pattern NameHomerSignificance
motif2.motif0.0500864
Etv6
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0058728
Pattern NameHomerSignificance
motif1.motif0.00912664
Erg
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
metacluster_1/pattern_110.0420147
Pattern NameHomerSignificance
motif1.motif0.00141053
Klf3
Pattern NameModiscoSignificance
metacluster_1/pattern_11.2780999999999998e-05
metacluster_1/pattern_80.039794699999999995
Pattern NameHomerSignificance
motif2.motif0.037344
Atf4
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0525279
metacluster_1/pattern_40.00616959
Pattern NameHomerSignificance
motif3.motif0.059038400000000005
Atf7
Pattern NameModiscoSignificance
metacluster_1/pattern_35.2358199999999996e-05
Pattern NameHomerSignificance
motif3.motif0.052172699999999995
motif6.motif0.0217796
Taf1
Pattern NameModiscoSignificance
metacluster_1/pattern_85.47234e-06
Pattern NameHomerSignificance
motif11.motif0.0006619460000000001
Tef
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0106866
metacluster_1/pattern_40.013297
Pattern NameHomerSignificance
motif3.motif0.059038400000000005
Cebpe
Pattern NameModiscoSignificance
metacluster_1/pattern_40.0157049
Pattern NameHomerSignificance
motif3.motif0.0343681
Pbx3
Pattern NameModiscoSignificance
metacluster_1/pattern_75.22205e-06
Pattern NameHomerSignificance
motif4.motif0.000282163
Spib
Pattern NameModiscoSignificance
metacluster_1/pattern_02.8430400000000004e-06
metacluster_1/pattern_120.0009991289999999999
metacluster_1/pattern_130.033230199999999994
Pattern NameHomerSignificance
motif1.motif0.016579
Bach1
Pattern NameModiscoSignificance
metacluster_1/pattern_60.000125785
Pattern NameHomerSignificance
motif3.motif0.0143095
Crem
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00173588
Pattern NameHomerSignificance
motif3.motif0.025343900000000003
motif6.motif0.050051599999999995
Egr2
Pattern NameModiscoSignificance
metacluster_1/pattern_10.055281500000000004
metacluster_1/pattern_80.0500575
Pattern NameHomerSignificance
motif2.motif0.029881400000000002
Mlx
Pattern NameModiscoSignificance
metacluster_1/pattern_100.026372700000000002
Pattern NameHomerSignificance
motif6.motif0.0326346
Zfp42
Pattern NameModiscoSignificance
metacluster_1/pattern_80.0187042
Pattern NameHomerSignificance
motif11.motif0.0144793
Clock
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0420894
Pattern NameHomerSignificance
motif6.motif0.0326346
Klf4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.017782
Pattern NameHomerSignificance
motif2.motif0.0357202
Nfyc
Pattern NameModiscoSignificance
metacluster_1/pattern_72.43458e-11
Pattern NameHomerSignificance
motif4.motif1.63886e-06
Nfe2
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00020946799999999998
Pattern NameHomerSignificance
motif3.motif0.0143095
Yy1
Pattern NameModiscoSignificance
metacluster_1/pattern_81.4801199999999998e-05
Pattern NameHomerSignificance
motif11.motif8.80524e-06
Elf3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.016066399999999998
Pattern NameHomerSignificance
motif1.motif0.00357354
Cebpa
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00673096
Pattern NameHomerSignificance
motif3.motif0.034477499999999994
Etv5
Pattern NameModiscoSignificance
metacluster_1/pattern_00.007196800000000001
Pattern NameHomerSignificance
motif1.motif3.6334299999999995e-05
Fos
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00030885900000000003
Pattern NameHomerSignificance
motif3.motif0.0223058
Tbx2
Pattern NameModiscoSignificance
metacluster_1/pattern_96.63534e-14
Pattern NameHomerSignificance
motif5.motif6.76414e-05
Irf8
Pattern NameModiscoSignificance
metacluster_1/pattern_04.5818699999999996e-05
metacluster_1/pattern_123.75237e-06
metacluster_1/pattern_130.0340518
Pattern NameHomerSignificance
motif1.motif0.023762400000000003
Arntl
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00548107
Pattern NameHomerSignificance
motif6.motif0.022210499999999998
Cebpg
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0355206
metacluster_1/pattern_40.0047512
Pattern NameHomerSignificance
motif3.motif0.0339541
Ddit3
Pattern NameModiscoSignificance
metacluster_1/pattern_40.00232538
Pattern NameHomerSignificance
motif3.motif0.0223058
Thap11
Pattern NameModiscoSignificance
metacluster_1/pattern_97.165739999999999e-21
Pattern NameHomerSignificance
motif5.motif1.10645e-06
Etv4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00799469
metacluster_1/pattern_110.0420147
Pattern NameHomerSignificance
motif1.motif0.00171391
Ctcf
Pattern NameModiscoSignificance
metacluster_1/pattern_21.3779999999999998e-11
Pattern NameHomerSignificance
motif10.motif6.87607e-05
Spdef
Pattern NameModiscoSignificance
metacluster_1/pattern_00.035459899999999996
Pattern NameHomerSignificance
motif1.motif0.0249797
Creb5
Pattern NameModiscoSignificance
metacluster_1/pattern_34.66329e-05
Pattern NameHomerSignificance
motif3.motif0.04683590000000001
motif6.motif0.00871147
Fosl2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00279567
metacluster_1/pattern_60.00109613
Pattern NameHomerSignificance
motif3.motif0.0332029
Atf3
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00430286
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.052172699999999995
motif6.motif0.032338099999999995
Klf7
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0008310310000000001
Pattern NameHomerSignificance
motif2.motif0.00454206
Mafk
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0274796
Pattern NameHomerSignificance
motif3.motif0.059038400000000005
Nrf1
Pattern NameModiscoSignificance
metacluster_1/pattern_51.75347e-08
Pattern NameHomerSignificance
motif8.motif7.97312e-07
Bach2
Pattern NameModiscoSignificance
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.010042200000000001
Mafb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00275545
metacluster_1/pattern_60.052031299999999996
Pattern NameHomerSignificance
motif6.motif0.04083030000000001
Atf1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.015092700000000002
metacluster_1/pattern_100.0145487
Pattern NameHomerSignificance
motif3.motif0.0505141
motif6.motif0.04083030000000001
Gabpa
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0431798
metacluster_1/pattern_110.00248793
Pattern NameHomerSignificance
motif1.motif0.00334837
Etv1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00799469
Pattern NameHomerSignificance
motif1.motif0.000209131
Jun
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0201731
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.0215945
Gmeb2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.042917500000000004
Pattern NameHomerSignificance
motif3.motif0.031209300000000002
Mitf
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0021098000000000002
Pattern NameHomerSignificance
motif6.motif0.0326346
Elk1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0058728
metacluster_1/pattern_110.0263969
Pattern NameHomerSignificance
motif1.motif0.00115945
Sp4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00233768
Pattern NameHomerSignificance
motif2.motif0.0144686
Srebf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00227077
Pattern NameHomerSignificance
motif6.motif0.0326346
Batf
Pattern NameModiscoSignificance
metacluster_1/pattern_60.00385253
Pattern NameHomerSignificance
motif3.motif0.0389041
Zfp143
Pattern NameModiscoSignificance
metacluster_1/pattern_94.603630000000001e-22
Pattern NameHomerSignificance
motif5.motif1.10645e-06
Cebpb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_40.00528144
Pattern NameHomerSignificance
motif3.motif0.059038400000000005
Fosl1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00316501
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.0292113
Bhlhe40
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00548107
Pattern NameHomerSignificance
motif6.motif0.0520092
Ets1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Pattern NameHomerSignificance
motif1.motif0.00152102
Srebf2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00321226
Pattern NameHomerSignificance
motif6.motif0.0595862
Jdp2
Pattern NameModiscoSignificance
metacluster_1/pattern_35.2358199999999996e-05
metacluster_1/pattern_60.00212269
Pattern NameHomerSignificance
motif3.motif0.030451599999999995
motif6.motif0.0217796
Klf8
Pattern NameModiscoSignificance
metacluster_1/pattern_10.00131391
Pattern NameHomerSignificance
motif2.motif0.00454206
Elf5
Pattern NameModiscoSignificance
metacluster_1/pattern_00.020663900000000002
Pattern NameHomerSignificance
motif1.motif0.00316431
Junb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_63.1446300000000004e-05
Pattern NameHomerSignificance
motif3.motif0.0400747
Irf4
Pattern NameModiscoSignificance
metacluster_1/pattern_05.64183e-05
metacluster_1/pattern_120.029095799999999998
metacluster_1/pattern_130.033230199999999994
Pattern NameHomerSignificance
motif1.motif0.0450686
Elk4
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00587973
Pattern NameHomerSignificance
motif1.motif0.000521135
Etv3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Pattern NameHomerSignificance
motif1.motif1.44525e-05
Creb1
Pattern NameModiscoSignificance
metacluster_1/pattern_30.00038311800000000005
Pattern NameHomerSignificance
motif3.motif0.034499699999999994
motif6.motif0.0104428
Elf1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00205757
Pattern NameHomerSignificance
motif1.motif0.00301844
Usf1
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00409131
Pattern NameHomerSignificance
motif6.motif0.0104428
Unique TF-MoDISco TFs: #48
TF NameModiscoHomer
Arnt
Pattern NameModiscoSignificance
metacluster_1/pattern_100.034058
Absent
Sp5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0153213
Absent
Zfx
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0587346
metacluster_1/pattern_80.00318115
metacluster_1/pattern_170.00309348
Absent
Stat2
Pattern NameModiscoSignificance
metacluster_1/pattern_120.000772417
Absent
Rfx2
Pattern NameModiscoSignificance
metacluster_1/pattern_140.0355302
Absent
Irf2
Pattern NameModiscoSignificance
metacluster_1/pattern_00.006852
metacluster_1/pattern_120.00125738
Absent
Klf5
Pattern NameModiscoSignificance
metacluster_1/pattern_10.025896199999999998
Absent
Rel
Pattern NameModiscoSignificance
metacluster_1/pattern_160.00550838
Absent
Sp3
Pattern NameModiscoSignificance
metacluster_1/pattern_11.54371e-05
metacluster_1/pattern_80.0007155169999999999
metacluster_1/pattern_170.00325765
Absent
Bhlhe41
Pattern NameModiscoSignificance
metacluster_1/pattern_100.013387
Absent
Tcfl5
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00408832
Absent
Rfx7
Pattern NameModiscoSignificance
metacluster_1/pattern_140.000581583
Absent
Mafa
Pattern NameModiscoSignificance
metacluster_1/pattern_60.040951
Absent
Maf
Pattern NameModiscoSignificance
metacluster_1/pattern_60.044366300000000004
Absent
Rorb
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
Absent
Rfx6
Pattern NameModiscoSignificance
metacluster_1/pattern_140.00121012
Absent
Mafg
Pattern NameModiscoSignificance
metacluster_1/pattern_60.0423286
Absent
Mlxip
Pattern NameModiscoSignificance
metacluster_1/pattern_100.04810759999999999
Absent
Sp2
Pattern NameModiscoSignificance
metacluster_1/pattern_18.60382e-06
metacluster_1/pattern_86.10787e-05
metacluster_1/pattern_170.000200947
Absent
Nfkb2
Pattern NameModiscoSignificance
metacluster_1/pattern_168.21883e-06
Absent
E2f4
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0005487469999999999
Absent
Zbtb17
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0101761
metacluster_1/pattern_80.016919299999999998
Absent
Irf7
Pattern NameModiscoSignificance
metacluster_1/pattern_123.83379e-05
Absent
Rfx3
Pattern NameModiscoSignificance
metacluster_1/pattern_140.000882345
Absent
E2f1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0200052
Absent
Arnt2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.0420894
Absent
Npas2
Pattern NameModiscoSignificance
metacluster_1/pattern_100.00315195
Absent
Rfx1
Pattern NameModiscoSignificance
metacluster_1/pattern_80.017743599999999998
metacluster_1/pattern_141.10901e-09
Absent
Pou3f3
Pattern NameModiscoSignificance
metacluster_1/pattern_40.0576943
Absent
Maz
Pattern NameModiscoSignificance
metacluster_1/pattern_80.039794699999999995
Absent
Relb
Pattern NameModiscoSignificance
metacluster_1/pattern_163.13794e-05
Absent
Nfia
Pattern NameModiscoSignificance
metacluster_1/pattern_201.08845e-05
Absent
Wt1
Pattern NameModiscoSignificance
metacluster_1/pattern_80.0310524
Absent
Pou2f2
Pattern NameModiscoSignificance
metacluster_1/pattern_187.720390000000001e-05
Absent
Nfkb1
Pattern NameModiscoSignificance
metacluster_1/pattern_166.846559999999999e-07
Absent
Irf9
Pattern NameModiscoSignificance
metacluster_1/pattern_120.0006986939999999999
Absent
Irf3
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00569724
metacluster_1/pattern_120.0006986939999999999
Absent
Irf1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.00862861
metacluster_1/pattern_125.957080000000001e-14
Absent
Rela
Pattern NameModiscoSignificance
metacluster_1/pattern_163.91498e-05
Absent
Creb3l2
Pattern NameModiscoSignificance
metacluster_1/pattern_30.0596692
metacluster_1/pattern_100.054163499999999996
Absent
Zfp281
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0347361
Absent
Prdm1
Pattern NameModiscoSignificance
metacluster_1/pattern_00.0051467
metacluster_1/pattern_122.69482e-05
Absent
Batf3
Pattern NameModiscoSignificance
metacluster_1/pattern_120.00656011
Absent
Klf6
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0005487469999999999
Absent
Rfx4
Pattern NameModiscoSignificance
metacluster_1/pattern_146.07901e-05
Absent
Klf1
Pattern NameModiscoSignificance
metacluster_1/pattern_10.0587346
Absent
Stat1
Pattern NameModiscoSignificance
metacluster_1/pattern_126.993220000000001e-05
Absent
Egr3
Pattern NameModiscoSignificance
metacluster_1/pattern_10.058297400000000006
Absent
Unique Homer TFs: #3
TF NameModiscoHomer
RxrbAbsent
Pattern NameHomerSignificance
motif6.motif0.022210499999999998
Snai1Absent
Pattern NameHomerSignificance
motif10.motif0.0394164
AhrAbsent
Pattern NameHomerSignificance
motif3.motif0.0586572